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dc.creatorConsiglio, Camila Rosat
dc.creatorCotugno, Nicola
dc.creatorSardh, Fabian
dc.creatorPou, Christian
dc.creatorAmodio, Donato
dc.creatorRodriguez, Lucie
dc.creatorTan, Ziyang
dc.creatorZicari, Sonia
dc.creatorRuggiero, Alessandra
dc.creatorPascucci, Giuseppe Rubens
dc.creatorSantilli, Veronica
dc.creatorCampbell, Tessa
dc.creatorBryceson, Yenan
dc.creatorEriksson, Daniel
dc.creatorWang, Jun
dc.creatorMarchesi, Alessandra
dc.creatorLakshmikanth, Tadepally
dc.creatorCampana, Andrea
dc.creatorVillani, Alberto
dc.creatorRossi, Paolo
dc.date.accessioned2020-09-30T16:06:52Z
dc.date.available2020-09-30T16:06:52Z
dc.date.created2020
dc.identifier.issn1097-4172spa
dc.identifier.otherhttps://doi.org/10.1016/j.cell.2020.09.016spa
dc.identifier.urihttp://hdl.handle.net/20.500.12010/14022
dc.description.abstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is typically very mild and often asymptomatic in children. A complication is the rare multisystem inflammatory syndrome in children (MISC) associated with COVID-19, presenting 4–6 weeks after infection as high fever, organ dysfunction, and strongly elevated markers of inflammation. The pathogenesis is unclear but has overlapping features with Kawasaki disease suggestive of vasculitis and a likely autoimmune etiology. We apply systems-level analyses of blood immune cells, cytokines, and autoantibodies in healthy children, children with Kawasaki disease enrolled prior to COVID-19, children infected with SARS-CoV-2, and children presenting with MIS-C. We find that the inflammatory response in MIS-C differs from the cytokine storm of severe acute COVID-19, shares several features with Kawasaki disease, but also differs from this condition with respect to T cell subsets, interleukin (IL)-17A, and biomarkers associated with arterial damage. Finally, autoantibody profiling suggests multiple autoantibodies that could be involved in the pathogenesis of MIS-C.spa
dc.format.extent22 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.publisherCellspa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectImmunologyspa
dc.subjectInflammatory Syndrome in Childrenspa
dc.subjectCOVID-19spa
dc.titleThe Immunology of Multisystem Inflammatory Syndrome in Children with COVID-19spa
dc.type.localArtículospa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.rights.localAbierto (Texto Completo)spa
dc.identifier.doihttps://doi.org/10.1016/j.cell.2020.09.016spa
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1spa


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