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dc.creatorTejera-Vaquerizo, A.
dc.creatorCanueto, J.
dc.creatorToll, A.
dc.creatorSantos-Juanes, J.
dc.creatorJaka, A.
dc.creatorFerrandiz, C.
dc.creatorSanmartín, O.
dc.creatorRibero, S.
dc.creatorMoreno-Ramírez, D.
dc.creatorAlmazan, F.
dc.creatorFuente, M.J.
dc.creatorPodlipnik, S.
dc.creatorNagore, E.
dc.date.accessioned2020-09-25T21:13:49Z
dc.date.available2020-09-25T21:13:49Z
dc.date.created2020
dc.identifier.issn1578-2190spa
dc.identifier.otherhttps://doi.org/10.1016/j.adengl.2020.09.008spa
dc.identifier.urihttp://hdl.handle.net/20.500.12010/13838
dc.description.abstractBackground and objectives: Spain is in a situation of indefinite lockdown due to the ongoing coronavirus disease 2019 (COVID-19) pandemic. One of the consequences of this lockdown is delays in medical and surgical procedures for common diseases. The aim of this study was to model the impact on survival of tumor growth caused by such delays in patients with squamous cell carcinoma (SCC) and melanoma. Material and methods. Multicenter, retrospective, observational cohort study. We constructed an exponential growth model for both SCC and melanoma to estimate tumor growth between patient-reported onset and surgical excision at different time points. Results. Data from 200 patients with SCC of the head and neck and 1000 patients with cutaneous melanoma were included. An exponential growth curve was calculated for each tumor type and we estimated tumor size after 1, 2, and 3 months of potential surgical delay. The proportion of patients with T3 SCC (diameter > 4 cm or thickness > 6 mm) increased from 41.5% (83 patients) in the initial study group to an estimated 58.5%, 70.5%, and 72% after 1, 2, and 3 months of delay. Disease-specific survival at 2, 5, and 10 years in patients whose surgery was delayed by 3 months decreased by 6.2%, 8.2%, and 5.2%, respectively. The proportion of patients with ultrathick melanoma (> 6 mm) increased from 6.9% in the initial study group to 21.9%, 30.2%, and 30.2% at 1, 2, and 3 months. Five- and 10-year disease-specific survival both decreased by 14.4% in patients treated after a potential delay of 3 months. Conclusions: In the absence of adequate diagnosis and treatment of SCC and melanoma in the current lockdown situation in Spain, we can expect to see to a considerable increase in large and thick SCCs and melanomas. Efforts must be taken to encourage self-examination and facilitate access to dermatologists in order to prevent further delays.spa
dc.format.extent22 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.publisherActas Dermo-Sifiliograficasspa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectMelanomaspa
dc.subjectPrognosisspa
dc.subjectEarly diagnosisspa
dc.subjectCutaneous squamous cell carcinomaspa
dc.subjectCOVID-19 virus diseasespa
dc.subjectLockdownspa
dc.titleEstimated effect of COVID-19 lockdown on skin tumor size and survival: an exponential growth modelspa
dc.type.localArtículospa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.rights.localAbierto (Texto Completo)spa
dc.identifier.doihttps://doi.org/10.1016/j.adengl.2020.09.008spa
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1spa


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