On the importance of early testing even when imperfect in a pandemic such as COVID- 19
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Resumo
As the COVID-19 pandemic unfolds, health departments rely upon
accurate surveillance systems to characterize local, regional, and national cases of the disease.With heterogenous symptomology, including
asymptomatic transmission, individuals may or may not receive diagnostic laboratory testing. The case definition offered by the World
Health Organization, and adopted by many health departments in the
U.S., only confirms a case based on a positive diagnostic test; an inconclusive test or unavailable test may be labeled a probable case [1]. A
false negative test result may not be identified as a case altogether.
Early on in the pandemic when the capacity for testing was limited,
the Centers for Disease Control and Prevention advised a priority-based
approach to testing for the SARS-CoV-2 virus, the etiologic agent of
COVID-19 disease, based on age, occupation, and morbidity [2].
Among those tested, the accuracy of the laboratory assay for SARSCoV-2 can make the difference between a false positive based on the
clinical findings that are attributable to another cause, or a false negative
based on lack of clinical findings that are attributable to SARS-CoV-2. As
such, testing has crucial implications on surveillance so that we can formulate a more informed response to the pandemic. Indeed, prior work
has demonstrated the potential for profound bias in epidemic curves
constructed from inaccurate COVID-19 surveillance data
Palabras clave
COVID- 19; PandemicLink para o recurso
https://doi.org/10.1016/j.gloepi.2020.100031Collections
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