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dc.creatorMoorlag, Simone J.C.F.M.
dc.creatorDeuren, Rosanne C. van
dc.creatorWerkhoven, Cornelis H. van
dc.creatorJaeger, Martin
dc.creatorDebisarun, Priya
dc.creatorTaks, Esther
dc.creatorMourits, Vera P.
dc.creatorKoeken, Valerie A.C.M.
dc.creatorBree, L. Charlotte J. de
dc.creatorDoesschate, Thijs ten
dc.creatorCleophas, Maartje C.
dc.creatorSmeekens, Sanne
dc.creatorOosting, Marije
dc.creatorVeerdonk, Frank L. van de
dc.creatorJoosten, Leo A.B.
dc.creatorOever, Jaap ten
dc.creatorMeer, Jos W.M. van der
dc.creatorCurtis, Nigel
dc.creatorAaby, Peter
dc.creatorStabell-Benn, Christine
dc.creatorGiamarellos-Bourboulis, Evangelos J.
dc.creatorBonten, Marc
dc.creatorCrevel, Reinout van
dc.creatorNetea, Mihai G.
dc.date.accessioned2020-09-25T15:59:27Z
dc.date.available2020-09-25T15:59:27Z
dc.date.created2020
dc.identifier.issn2666-3791spa
dc.identifier.otherhttps://doi.org/10.1016/j.xcrm.2020.100073spa
dc.identifier.urihttp://hdl.handle.net/20.500.12010/13797
dc.description.abstractBacille Calmette-Gue´rin (BCG) induces long-term boosting of innate immunity, termed trained immunity, and decreases susceptibility to respiratory tract infections. BCG vaccination trials for reducing SARS-CoV-2 infection are underway, but concerns have been raised regarding the potential harm of strong innate immune responses. To investigate the safety of BCG vaccination, we retrospectively assessed coronavirus disease 2019 (COVID-19) and related symptoms in three cohorts of healthy volunteers who either received BCG in the last 5 years or did not. BCG vaccination is not associated with increased incidence of symptoms during the COVID-19 outbreak in the Netherlands. Our data suggest that BCG vaccination might be associated with a decrease in the incidence of sickness during the COVID-19 pandemic (adjusted odds ratio [AOR] 0.58, p < 0.05), and lower incidence of extreme fatigue. In conclusion, recent BCG vaccination is safe, and large randomized trials are needed to reveal if BCG reduces the incidence and/or severity of SARS-CoV-2 infection.spa
dc.format.extent16 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.publisherCell reports medicinespa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectCOVID-19spa
dc.subjectSymptomsspa
dc.subjectRecently vaccinatedspa
dc.subjectBCGspa
dc.titleSafety and COVID-19 symptoms in individuals recently vaccinated with BCG: A retrospective cohort studyspa
dc.type.localArtículospa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.rights.localAbierto (Texto Completo)spa
dc.identifier.doihttps://doi.org/10.1016/j.xcrm.2020.100073spa
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1spa


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