Sex differences underlying preexisting cardiovascular disease and cardiovascular injury in COVID-19
Fecha
2020Autor
Medzikovic, Lejla
Cunningham, Christine M.
Li, Min
Amjedi, Marjan
Hong, Jason
Ruffenach, Gregoire
Eghbali, Mansoureh
Documentos PDF
Resumen
The novel 2019 coronavirus disease (COVID-19), resulting from severe acute respiratory syndrome coronarvirus2 (SARS-CoV-2) infection, typically leads to respiratory failure in severe cases; however, cardiovascular injury is
reported to contribute to a substantial proportion of COVID-19 deaths. Preexisting cardiovascular disease (CVD)
is among the most common risk factors for hospitalization and death in COVID-19 patients, and the pathogenic
mechanisms of COVID-19 disease progression itself may promote the development of cardiovascular injury,
increasing risk of in-hospital death. Sex differences in COVID-19 are becoming more apparent as mounting data
indicate that males seem to be disproportionately at risk of severe COVID-19 outcome due to preexisting CVD
and COVID-19-related cardiovascular injury. In this review, we will provide a basic science perspective on
current clinical observations in this rapidly evolving field and discuss the interplay sex differences, preexisting
CVD and COVID-19-related cardiac injury
Palabras clave
Sex differences; Cardiovascular; COVID-19; ACE2; Arrhythmia; ThrombosisEnlace al recurso
https://doi.org/10.1016/j.yjmcc.2020.08.007Colecciones
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