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dc.creatorSekine, Takuya
dc.creatorPerez-Potti, André
dc.creatorRivera-Ballesteros, Olga
dc.creatorStrålin, Kristoffer
dc.creatorBaptiste Gorin, Jean
dc.creatorOlsson, Annika
dc.creatorLlewellyn-Lacey, Sian
dc.creatorKamal, Habiba
dc.creatorBogdanovic, Gordana
dc.creatorMuschiol, Sandra
dc.creatorWullimann, David J.
dc.creatorKammann, Tobias
dc.creatorEmgård, Johanna
dc.creatorParrot, Tiphaine
dc.creatorFolkesson, Elin
dc.creatorRooyackers, Olav
dc.creatorEriksson, Lars I.
dc.creatorHenter, JanInge
dc.creatorSönnerborg, Anders
dc.creatorAllander, Tobias
dc.creatorAlbert, Jan
dc.creatorNielsen, Morten
dc.creatorKlingström, Jonas
dc.creatorGredmark-Russ, Sara
dc.creatorBjörkström, Niklas K.
dc.creatorSandberg, Johan K.
dc.creatorPrice, David A.
dc.creatorLjunggren, Hans-Gustaf
dc.creatorAleman, Soo
dc.creatorBuggert, Marcus
dc.date.accessioned2020-09-23T15:15:14Z
dc.date.available2020-09-23T15:15:14Z
dc.date.created2020
dc.identifier.issn0092-8674spa
dc.identifier.otherhttps://doi.org/10.1016/j.cell.2020.08.017spa
dc.identifier.urihttp://hdl.handle.net/20.500.12010/13676
dc.description.abstractSARS-CoV-2-specific memory T cells will likely prove critical for long-term immune protection against COVID-19. We here systematically mapped the functional and phenotypic landscape of SARS-CoV-2-specific T cell responses in unexposed individuals, exposed family members, and individuals with acute or convalescent COVID-19. Acute phase SARS-CoV-2-specific T cells displayed a highly activated cytotoxic phenotype that correlated with various clinical markers of disease severity, whereas convalescent phase SARS-CoV-2-specific T cells were polyfunctional and displayed a stem-like memory phenotype. Importantly, SARS-CoV-2-specific T cells were detectable in antibody-seronegative exposed family members and convalescent individuals with a history of asymptomatic and mild COVID-19. Our collective dataset shows that SARS-CoV-2 elicits robust, broad and highly functional memory T cell responses, suggesting that natural exposure or infection may prevent recurrent episodes of severe COVID-19.spa
dc.format.extent46 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.publisherCellspa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectCOVID-19spa
dc.subjectRobust Tspa
dc.subjectCell immunityspa
dc.titleRobust T cell immunity in convalescent individuals with asymptomatic or mild COVID-19spa
dc.type.localArtículospa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.rights.localAbierto (Texto Completo)spa
dc.identifier.doihttps://doi.org/10.1016/j.cell.2020.08.017spa
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1spa


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