Robust T Cell Response Toward Spike, Membrane, and Nucleocapsid SARS-CoV-2 Proteins Is Not Associated with Recovery in Critical COVID-19 Patients
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Date
2020Author
Thieme, Constantin J.
Anft, Moritz
Paniskaki, Krystallenia
Blazquez-Navarro, Arturo
Doevelaar, Adrian
Seibert, Felix S.
Hoelzer, Bodo
Konik, Margarethe Justine
Moritz Berger, Marc
Brenner, Thorsten
Tempfer, Clemens
Watzl, Carsten
Meister, Toni L.
Pfaender, Stephanie
Steinmann, Eike
Dolff, Sebastian
Dittmer, Ulf
Westhoff, Timm H.
Witzke, Oliver
Stervbo, Ulrik
Roch, Toralf
Babel, Nina
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Abstract
T cell immunity toward SARS-CoV-2 spike (S-), membrane (M-), and nucleocapsid (N-) proteins may define
COVID-19 severity. Therefore, we compare the SARS-CoV-2-reactive T cell responses in moderate, severe,
and critical COVID-19 patients and unexposed donors. Overlapping peptide pools of all three proteins induce
SARS-CoV-2-reactive T cell response with dominance of CD4+ over CD8+ T cells and demonstrate interindividual immunity against the three proteins. M-protein induces the highest frequencies of CD4+ T cells, suggesting its relevance for diagnosis and vaccination. The T cell response of critical COVID-19 patients is robust
and comparable or even superior to non-critical patients. Virus clearance and COVID-19 survival are not
associated with either SARS-CoV-2 T cell kinetics or magnitude of T cell responses, respectively. Thus,
our data do not support the hypothesis of insufficient SARS-CoV-2-reactive immunity in critical COVID-19.
Conversely, it indicates that activation of differentiated memory effector T cells could cause hyperreactivity
and immunopathogenesis in critical patients.
Palabras clave
Robust T Cell; Response Toward Spike; COVID-19Link to resource
https://doi.org/10.1016/j.xcrm.2020.100092Collections
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