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dc.creatorYasui, Yukako
dc.creatorYasui, Hiroyuki
dc.creatorSuzuki, Kumiko
dc.creatorSaitou, Takako
dc.creatorYamamoto, Yoshiki
dc.creatorIshizaka, Toshihiko
dc.creatorNishida, Kouji
dc.creatorYoshihara, Shingo
dc.creatorGohma, Iwao
dc.creatorOgawa, Yoshihiko
dc.date.accessioned2020-09-22T19:41:00Z
dc.date.available2020-09-22T19:41:00Z
dc.date.created2020
dc.identifier.issn1201-9712spa
dc.identifier.otherhttps://doi.org/10.1016/j.ijid.2020.09.008spa
dc.identifier.urihttp://hdl.handle.net/20.500.12010/13599
dc.description.abstractObjectives: Because most severely ill patients with COVID-19 in our hospital showed zinc deficiency, we aimed to examine the relationship between the patient’s serum zinc level and severe cases of COVID-19. Methods: Serum zinc <70 µg/dL was defined as the criterion for hypozincemia, and patients continuously with serum zinc <70 µg/dL were classified in the hypozincemia cohort. To evaluate whether hypozincemia could be a predictive factor for critical illness of COVID-19, we performed the multivariate analysis by employing logistic regression analysis. Results: Prolonged hypozincemia was found to be a risk factor for a severe case of COVID-19. In evaluating the relationship between the serum zinc level and severity of patients with COVID-19 by multivariate logistic regression analysis, critical illness can be predicted through the sensitivity and false specificity of an ROC curve with an error rate of 10.3% and AUC of 94.2% by only two factors: serum zinc value (P=0.020) and LDH value (P=0.026). Conclusions: Proper management of the prediction results in this study can contribute to the establishment and maintenance of a safe medical system, taking the arrival of the second wave and spread of COVID Journal Pre-proof -19 in the future into consideration.spa
dc.format.extent42 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.publisherInternational Journal of Infectious Diseasesspa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectCOVID-19spa
dc.subjectSerum Zincspa
dc.subjectPredictive Factorsspa
dc.subjectLogistic Regression Analysisspa
dc.subjectCritical Illnessspa
dc.subjectJapanspa
dc.titleAnalysis of the predictive factors for critical illness of COVID-19 during treatment - Relationship between serum zinc level and critical illness of COVID-19spa
dc.type.localArtículospa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.rights.localAbierto (Texto Completo)spa
dc.identifier.doihttps://doi.org/10.1016/j.ijid.2020.09.008spa
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1spa


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