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Acute Encephalopathy Is Associated With Worse Outcomes In COVID-19 Patients
| dc.creator | Shah, Vishank Arun | |
| dc.creator | Nalleballe, Krishna | |
| dc.creator | Zaghlouleh, Ezzat | |
| dc.creator | Onteddu, Sanjeeva | |
| dc.date.accessioned | 2020-09-22T15:01:02Z | |
| dc.date.available | 2020-09-22T15:01:02Z | |
| dc.date.created | 2020-08-25 | |
| dc.identifier.issn | 2666-3546 | spa |
| dc.identifier.other | https://www.sciencedirect.com/science/article/pii/S2666354620301010?via%3Dihub#! | spa |
| dc.identifier.uri | http://hdl.handle.net/20.500.12010/13555 | |
| dc.format.extent | 19 páginas | spa |
| dc.format.mimetype | application/pdf | spa |
| dc.language.iso | spa | spa |
| dc.publisher | Brain, Behavior, & Immunity - Health | spa |
| dc.source | reponame:Expeditio Repositorio Institucional UJTL | spa |
| dc.source | instname:Universidad de Bogotá Jorge Tadeo Lozano | spa |
| dc.subject | outcomes | spa |
| dc.subject | encephalopathy | spa |
| dc.title | Acute Encephalopathy Is Associated With Worse Outcomes In COVID-19 Patients | spa |
| dc.type.local | Artículo | spa |
| dc.subject.lemb | Síndrome respiratorio agudo grave | spa |
| dc.subject.lemb | COVID-19 | spa |
| dc.subject.lemb | SARS-CoV-2 | spa |
| dc.subject.lemb | Coronavirus | spa |
| dc.rights.accessrights | info:eu-repo/semantics/restrictedAccess | spa |
| dc.type.hasversion | info:eu-repo/semantics/acceptedVersion | spa |
| dc.rights.local | Acceso restringido | spa |
| dc.identifier.doi | https://doi.org/10.1016/j.bbih.2020.100136 | spa |
| dc.description.abstractenglish | Background Acute encephalopathy with COVID-19 has been reported in several studies but its impact on outcomes remains unclear. We hypothesized that hospitalized COVID-19 patients with encephalopathy have worse COVID-19 related outcomes. Methods We used TriNetX, with a large COVID-19 database, collecting real-time electronic medical records data. We included hospitalized COVID-19 patients since January 20, 2020 who had encephalopathy based on ICD-10 coding. We examined clinical outcomes comprising need for critical care services, intubation and mortality among these patients and compared it with patients without encephalopathy before and after propensity-score matching. Results Of 12,601 hospitalized COVID-19 patients, 1092 (8.7%) developed acute encephalopathy. Patients in the acute encephalopathy group were older (67 vs. 61 years) and had higher prevalence of medical co-morbidities including obesity, hypertension, diabetes, heart disease, COPD, chronic kidney and liver disease among others. Before and after propensity score-matching for co-morbidities, patients with acute encephalopathy were more likely to need critical care services (35.6% vs. 16.9%, p < 0.0001), intubation (19.5% vs. 6.0%, p<0.0001) and had higher 30-day mortality (24.3% vs. 17.9%, p 0.0002). Conclusion Among hospitalized COVID-19 patients, acute encephalopathy is common and more likely to occur in patients with medical co-morbidities and are more likely to need critical care, intubation and have higher 30-day mortality even after adjusting for age and underlying medical co-morbidities. | spa |
| dc.type.coar | http://purl.org/coar/resource_type/c_6501 | spa |
