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Single-cell transcriptomic atlas of primate cardiopulmonary aging
| dc.creator | Ma, Shuai | |
| dc.creator | Sun, Shuhui | |
| dc.creator | Li, Jiaming | |
| dc.creator | Fan, Yanling | |
| dc.creator | Qu, Jing | |
| dc.creator | Sun, Liang | |
| dc.creator | Wang, Si | |
| dc.creator | Zhang, Yiyuan | |
| dc.creator | Yang, Shanshan | |
| dc.creator | Liu, Zunpeng | |
| dc.creator | Wu, Zeming | |
| dc.creator | Zhang, Sheng | |
| dc.creator | Wang, Qiaoran | |
| dc.creator | Zheng, Aihua | |
| dc.creator | Duo, Shuguang | |
| dc.creator | Yu, Yang | |
| dc.creator | Izpisua Belmonte, Juan Carlos | |
| dc.creator | Chan, Piu | |
| dc.creator | Zhou, Qi | |
| dc.creator | Song, Moshi | |
| dc.creator | Zhang, Weiqi | |
| dc.creator | Liu, Guang-Hui | |
| dc.date.accessioned | 2020-09-18T16:28:52Z | |
| dc.date.available | 2020-09-18T16:28:52Z | |
| dc.date.created | 2020-06-29 | |
| dc.identifier.issn | 1748-7838 | spa |
| dc.identifier.other | https://www.nature.com/articles/s41422-020-00412-6 | spa |
| dc.identifier.uri | http://hdl.handle.net/20.500.12010/13458 | |
| dc.format.extent | 18 páginas | spa |
| dc.format.mimetype | application/pdf | spa |
| dc.language.iso | eng | spa |
| dc.publisher | Cell Research | spa |
| dc.source | reponame:Expeditio Repositorio Institucional UJTL | spa |
| dc.source | instname:Universidad de Bogotá Jorge Tadeo Lozano | spa |
| dc.subject | Single-cell transcriptomic atlas | spa |
| dc.subject | primate cardiopulmonary aging | spa |
| dc.subject | cardiopulmonary | spa |
| dc.title | Single-cell transcriptomic atlas of primate cardiopulmonary aging | spa |
| dc.type.local | Artículo | spa |
| dc.subject.lemb | Síndrome respiratorio agudo grave | spa |
| dc.subject.lemb | COVID-19 | spa |
| dc.subject.lemb | SARS-CoV-2 | spa |
| dc.subject.lemb | Coronavirus | spa |
| dc.rights.accessrights | info:eu-repo/semantics/restrictedAccess | spa |
| dc.type.hasversion | info:eu-repo/semantics/acceptedVersion | spa |
| dc.rights.local | Acceso restringido | spa |
| dc.identifier.doi | https://doi.org/10.1038/s41422-020-00412-6 | spa |
| dc.description.abstractenglish | Aging is a major risk factor for many diseases, especially in highly prevalent cardiopulmonary comorbidities and infectious diseases including Coronavirus Disease 2019 (COVID-19). Resolving cellular and molecular mechanisms associated with aging in higher mammals is therefore urgently needed. Here, we created young and old non-human primate single-nucleus/cell transcriptomic atlases of lung, heart and artery, the top tissues targeted by SARS-CoV-2. Analysis of cell type-specific aging-associated transcriptional changes revealed increased systemic inflammation and compromised virus defense as a hallmark of cardiopulmonary aging. With age, expression of the SARS-CoV-2 receptor angiotensin-converting enzyme 2 (ACE2) was increased in the pulmonary alveolar epithelial barrier, cardiomyocytes, and vascular endothelial cells. We found that interleukin 7 (IL7) accumulated in aged cardiopulmonary tissues and induced ACE2 expression in human vascular endothelial cells in an NF-κB-dependent manner. Furthermore, treatment with vitamin C blocked IL7-induced ACE2 expression. Altogether, our findings depict the first transcriptomic atlas of the aged primate cardiopulmonary system and provide vital insights into age-linked susceptibility to SARS-CoV-2, suggesting that geroprotective strategies may reduce COVID-19 severity in the elderly. | spa |
| dc.type.coar | http://purl.org/coar/resource_type/c_6501 | spa |
