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dc.creatorWu, Sean L.
dc.creatorMertens, Andrew N.
dc.creatorCrider, Yoshika S.
dc.creatorNguyen, Anna
dc.creatorPokpongkiat, Nolan N.
dc.creatorDjajadi, Stephanie
dc.creatorSeth, Anmol
dc.creatorHsiang, Michelle S.
dc.creatorColford Jr., John M.
dc.creatorReingold, Art
dc.creatorArnold, Benjamin F.
dc.creatorHubbard, Alan
dc.creatorBenjamin-Chung, Jade
dc.date.accessioned2020-09-18T15:15:36Z
dc.date.available2020-09-18T15:15:36Z
dc.date.created2020
dc.identifier.issn2041-1723spa
dc.identifier.otherhttps://doi.org/10.1038/s41467-020-18272-4spa
dc.identifier.urihttp://hdl.handle.net/20.500.12010/13453
dc.description.abstractAccurate estimates of the burden of SARS-CoV-2 infection are critical to informing pandemic response. Confirmed COVID-19 case counts in the U.S. do not capture the total burden of the pandemic because testing has been primarily restricted to individuals with moderate to severe symptoms due to limited test availability. Here, we use a semi-Bayesian probabilistic bias analysis to account for incomplete testing and imperfect diagnostic accuracy. We estimate 6,454,951 cumulative infections compared to 721,245 confirmed cases (1.9% vs. 0.2% of the population) in the United States as of April 18, 2020. Accounting for uncertainty, the number of infections during this period was 3 to 20 times higher than the number of confirmed cases. 86% (simulation interval: 64–99%) of this difference is due to incomplete testing, while 14% (0.3–36%) is due to imperfect test accuracy. The approach can readily be applied in future studies in other locations or at finer spatial scale to correct for biased testing and imperfect diagnostic accuracy to provide a more realistic assessment of COVID-19 burden.spa
dc.format.extent10 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.publisherNature communicationsspa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectSARS-CoV-2spa
dc.subjectSARS-CoV-2 Infectionspa
dc.subjectUnited Statesspa
dc.titleSubstantial underestimation of SARS-CoV-2 infection in the United Statesspa
dc.type.localArtículospa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.rights.localAbierto (Texto Completo)spa
dc.identifier.doihttps://doi.org/10.1038/s41467-020-18272-4spa
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1spa


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