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dc.creatorYang, Jinsung
dc.creatorPetitjean, Simon J. L.
dc.creatorKoehler, Melanie
dc.creatorZhang, Qingrong
dc.creatorDumitru, Andra C.
dc.creatorChen, Wenzhang
dc.creatorDerclaye, Sylvie
dc.creatorVincent, Stéphane P.
dc.creatorSoumillion, Patrice
dc.creatorAlsteens, David
dc.date.accessioned2020-09-18T14:30:44Z
dc.date.available2020-09-18T14:30:44Z
dc.date.created2020
dc.identifier.issn1546-170Xspa
dc.identifier.otherhttps://doi.org/10.1038/s41467-020-18319-6spa
dc.identifier.urihttp://hdl.handle.net/20.500.12010/13449
dc.description.abstractStudy of the interactions established between the viral glycoproteins and their host receptors is of critical importance for a better understanding of virus entry into cells. The novel coronavirus SARS-CoV-2 entry into host cells is mediated by its spike glycoprotein (S-glycoprotein), and the angiotensin-converting enzyme 2 (ACE2) has been identified as a cellular receptor. Here, we use atomic force microscopy to investigate the mechanisms by which the S-glycoprotein binds to the ACE2 receptor. We demonstrate, both on model surfaces and on living cells, that the receptor binding domain (RBD) serves as the binding interface within the S-glycoprotein with the ACE2 receptor and extract the kinetic and thermodynamic properties of this binding pocket. Altogether, these results provide a picture of the established interaction on living cells. Finally, we test several binding inhibitor peptides targeting the virus early attachment stages, offering new perspectives in the treatment of the SARS-CoV-2 infection.spa
dc.format.extent10 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.publisherNature communicatiosspa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectMolecular interactionspa
dc.subjectSARS-CoV-2spa
dc.subjectACE2 receptorspa
dc.titleMolecular interaction and inhibition of SARS-CoV-2 binding to the ACE2 receptorspa
dc.type.localArtículospa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.rights.localAbierto (Texto Completo)spa
dc.identifier.doihttps://doi.org/10.1038/s41467-020-18319-6spa
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1spa


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