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dc.creatorDeng, Wei
dc.creatorBao, Linlin
dc.creatorGao, Hong
dc.creatorXiang, Zhiguang
dc.creatorQu, Yajin
dc.creatorSong, Zhiqi
dc.creatorGong, Shuran
dc.creatorLiu, Jiayi
dc.creatorLiu, Jiangning
dc.creatorYu, Pin
dc.creatorQi, Feifei
dc.creatorXu, Yanfeng
dc.creatorLi, Fengli
dc.creatorXiao, Chong
dc.creatorLv, Qi
dc.creatorXue, Jing
dc.creatorWei, Qiang
dc.creatorLiu, Mingya
dc.creatorWang, Guanpeng
dc.creatorWang, Shunyi
dc.creatorYu, Haisheng
dc.creatorChen, Ting
dc.creatorLiu, Xing
dc.creatorZhao, Wenjie
dc.creatorHan, Yunlin
dc.creatorQin, Chuan
dc.date.accessioned2020-09-18T03:04:45Z
dc.date.available2020-09-18T03:04:45Z
dc.date.created2020-09-02
dc.identifier.issn2041-1723spa
dc.identifier.otherhttps://www.nature.com/articles/s41467-020-18149-6#article-infospa
dc.identifier.urihttp://hdl.handle.net/20.500.12010/13436
dc.format.extent7 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.publisherNature Communicationsspa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectSARS-CoV-2spa
dc.titleOcular conjunctival inoculation of SARS-CoV-2 can cause mild COVID-19 in rhesus macaquesspa
dc.type.localArtículospa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.rights.localAbierto (Texto Completo)spa
dc.identifier.doihttps://doi.org/10.1038/s41467-020-18149-6spa
dc.description.abstractenglishSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is highly transmitted through the respiratory route, but potential extra-respiratory routes of SARS-CoV-2 transmission remain uncertain. Here we inoculated five rhesus macaques with 1 × 106 TCID50 of SARS-CoV-2 conjunctivally (CJ), intratracheally (IT), and intragastrically (IG). Nasal and throat swabs collected from CJ and IT had detectable viral RNA at 1–7 days post-inoculation (dpi). Viral RNA was detected in anal swabs from only the IT group at 1–7 dpi. Viral RNA was undetectable in tested swabs and tissues after intragastric inoculation. The CJ infected animal had a higher viral load in the nasolacrimal system than the IT infected animal but also showed mild interstitial pneumonia, suggesting distinct virus distributions. This study shows that infection via the conjunctival route is possible in non-human primates; further studies are necessary to compare the relative risk and pathogenesis of infection through these different routes in more detail.spa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa


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