Show simple item record

dc.creatorFeng, Liqiang
dc.creatorWang, Qian
dc.creatorShan, Chao
dc.creatorYang, Chenchen
dc.creatorFeng, Ying
dc.creatorWu, Jia
dc.creatorLiu, Xiaolin
dc.creatorZhou, Yiwu
dc.creatorJiang, Rendi
dc.creatorHu, Peiyu
dc.creatorLiu, Xinglong
dc.creatorZhang, Fan
dc.creatorLi, Pingchao
dc.creatorNiu, Xuefeng
dc.creatorLiu, Yichu
dc.creatorZheng, Xuehua
dc.creatorLuo, Jia
dc.creatorSun, Jing
dc.creatorGu, Yingying
dc.creatorLiu, Bo
dc.creatorXu, Yongcun
dc.creatorLi, Chufang
dc.creatorPan, Weiqi
dc.creatorZhao, Jincun
dc.creatorKe, Changwen
dc.creatorChen, Xinwen
dc.creatorXu, Tao
dc.creatorZhong, Nanshan
dc.creatorGuan, Suhua
dc.creatorYuan, Zhiming
dc.creatorChen, Ling
dc.date.accessioned2020-09-18T02:48:24Z
dc.date.available2020-09-18T02:48:24Z
dc.date.created2020-08-21
dc.identifier.issn2041-1723spa
dc.identifier.otherhttps://www.nature.com/articles/s41467-020-18077-5spa
dc.identifier.urihttp://hdl.handle.net/20.500.12010/13432
dc.format.extent11 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.publisherNature Communicationsspa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectCOVID-19spa
dc.titleAn adenovirus-vectored COVID-19 vaccine confers protection from SARS-COV-2 challenge in rhesus macaquesspa
dc.type.localArtículospa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.rights.localAbierto (Texto Completo)spa
dc.subject.keywordVaccinesspa
dc.identifier.doihttps://doi.org/10.1038/s41467-020-18077-5spa
dc.description.abstractenglishThe rapid spread of coronavirus SARS-CoV-2 greatly threatens global public health but no prophylactic vaccine is available. Here, we report the generation of a replication-incompetent recombinant serotype 5 adenovirus, Ad5-S-nb2, carrying a codon-optimized gene encoding Spike protein (S). In mice and rhesus macaques, intramuscular injection with Ad5-S-nb2 elicits systemic S-specific antibody and cell-mediated immune (CMI) responses. Intranasal inoculation elicits both systemic and pulmonary antibody responses but weaker CMI response. At 30 days after a single vaccination with Ad5-S-nb2 either intramuscularly or intranasally, macaques are protected against SARS-CoV-2 challenge. A subsequent challenge reveals that macaques vaccinated with a 10-fold lower vaccine dosage (1 × 1010 viral particles) are also protected, demonstrating the effectiveness of Ad5-S-nb2 and the possibility of offering more vaccine dosages within a shorter timeframe. Thus, Ad5-S-nb2 is a promising candidate vaccine and warrants further clinical evaluation.spa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record