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dc.creatorJunior, Hany Simon
dc.creatorSakano, Tania Miyuki Shimoda
dc.creatorRodrigues, Regina Maria
dc.creatorEisencraft, Adriana Pasmanik
dc.creatorCarvalho, Vitor Emanoel Lemos de
dc.creatorSchvartsman, Claudio
dc.creatorReis, Amelia Gorete Afonso da Costa
dc.date.accessioned2020-09-18T01:30:25Z
dc.date.available2020-09-18T01:30:25Z
dc.date.created2020-09-11
dc.identifier.issn0021-7557spa
dc.identifier.otherhttps://www.sciencedirect.com/science/article/pii/S0021755720302035?via%3Dihubspa
dc.identifier.urihttp://hdl.handle.net/20.500.12010/13417
dc.format.extent20 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.publisherJornal de Pediatriaspa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectCOVID-19spa
dc.titleMultisystem inflammatory syndrome associated with COVID-19 from the pediatric emergency physician's point of viewspa
dc.type.localArtículospa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.rights.localAbierto (Texto Completo)spa
dc.subject.keywordCoronavirus disease (COVID-19)spa
dc.subject.keywordEmergency departmentspa
dc.subject.keywordInflammatory syndromespa
dc.subject.keywordKawasaki diseasespa
dc.subject.keywordPediatricsspa
dc.subject.keywordSARS-CoV-2spa
dc.identifier.doihttps://doi.org/10.1016/j.jped.2020.08.004spa
dc.description.abstractenglishObjective Multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus disease (COVID-19) is a rare and challenging diagnosis requiring early treatment. The diagnostic criteria involve clinical, laboratory, and complementary tests. This review aims to draw pediatrician attention to this diagnosis, suggesting early treatment strategies, and proposing a pediatric emergency care flowchart. Sources The PubMed/MEDLINE/WHO COVID-19 databases were reviewed for original and review articles, systematic reviews, meta-analyses, case series, and recommendations from medical societies and health organizations published through July 3, 2020. The reference lists of the selected articles were manually searched to identify any additional articles. Summary of the findings COVID-19 infection is less severe in children than in adults, but can present as MIS-C, even in patients without comorbidities. There is evidence of an exacerbated inflammatory response with potential systemic injury, and it may present with aspects similar to those of Kawasaki disease, toxic shock syndrome, and macrophage activation syndrome. MIS-C can develop weeks after COVID-19 infection, suggesting an immunomediated cause. The most frequent clinical manifestations include fever, gastrointestinal symptoms, rash, mucous membrane changes, and cardiac dysfunction. Elevated inflammatory markers, lymphopenia, and coagulopathy are common laboratory findings. Supportive treatment and early immunomodulation can control the intense inflammatory response and reduce complications and mortality. Conclusions MIS-C associated with COVID-19 is serious, rare, and potentially fatal. The emergency department pediatrician must recognize and treat it early using immunomodulatory strategies to reduce systemic injury. Further studies are needed to identify the disease pathogenesis and establish the most appropriate treatment.spa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa


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