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dc.creatorIsabel, Sandra
dc.creatorGraña‑Miraglia, Lucía
dc.creatorGutierrez, Jahir M.
dc.creatorBundalovic‑Torma, Cedoljub
dc.creatorGroves, Helen E.
dc.creatorIsabel, Marc R.
dc.creatorEshagh, AliReza
dc.creatorPate, Samir N.
dc.creatorGubbay, Jonathan B.
dc.creatorPoutanen, Tomi
dc.creatorGuttman, David S.
dc.creatorPoutanen, Susan M.
dc.date.accessioned2020-09-17T21:07:46Z
dc.date.available2020-09-17T21:07:46Z
dc.date.created2020
dc.identifier.issn2045 2322spa
dc.identifier.otherhttps://doi.org/10.1038/s41598-020-70827-zspa
dc.identifier.urihttp://hdl.handle.net/20.500.12010/13391
dc.description.abstractThe COVID-19 pandemic, caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARSCoV-2), was declared on March 11, 2020 by the World Health Organization. As of the 31st of May, 2020, there have been more than 6 million COVID-19 cases diagnosed worldwide and over 370,000 deaths, according to Johns Hopkins. Thousands of SARS-CoV-2 strains have been sequenced to date, providing a valuable opportunity to investigate the evolution of the virus on a global scale. We performed a phylogenetic analysis of over 1,225 SARS-CoV-2 genomes spanning from late December 2019 to mid-March 2020. We identifed a missense mutation, D614G, in the spike protein of SARSCoV-2, which has emerged as a predominant clade in Europe (954 of 1,449 (66%) sequences) and is spreading worldwide (1,237 of 2,795 (44%) sequences). Molecular dating analysis estimated the emergence of this clade around mid-to-late January (10–25 January) 2020. We also applied structural bioinformatics to assess the potential impact of D614G on the virulence and epidemiology of SARSCoV-2. In silico analyses on the spike protein structure suggests that the mutation is most likely neutral to protein function as it relates to its interaction with the human ACE2 receptor. The lack of clinical metadata available prevented our investigation of association between viral clade and disease severity phenotype. Future work that can leverage clinical outcome data with both viral and human genomic diversity is needed to monitor the pandemic.spa
dc.format.extent9 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.publisherScientific reportsspa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectSARS‑CoV‑2spa
dc.subjectD614Gspa
dc.subjectSpike proteinspa
dc.titleEvolutionary and structural analyses of SARS‐CoV‐2 D614G spike protein mutation now documented worldwidespa
dc.type.localArtículospa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.rights.localAbierto (Texto Completo)spa
dc.identifier.doihttps://doi.org/10.1038/s41598-020-70827-zspa
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1spa


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