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Evolutionary and structural analyses of SARS‐CoV‐2 D614G spike protein mutation now documented worldwide

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Date
2020
Author
Isabel, Sandra
Graña‑Miraglia, Lucía
Gutierrez, Jahir M.
Bundalovic‑Torma, Cedoljub
Groves, Helen E.
Isabel, Marc R.
Eshagh, AliReza
Pate, Samir N.
Gubbay, Jonathan B.
Poutanen, Tomi
Guttman, David S.
Poutanen, Susan M.
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Abstract
The COVID-19 pandemic, caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARSCoV-2), was declared on March 11, 2020 by the World Health Organization. As of the 31st of May, 2020, there have been more than 6 million COVID-19 cases diagnosed worldwide and over 370,000 deaths, according to Johns Hopkins. Thousands of SARS-CoV-2 strains have been sequenced to date, providing a valuable opportunity to investigate the evolution of the virus on a global scale. We performed a phylogenetic analysis of over 1,225 SARS-CoV-2 genomes spanning from late December 2019 to mid-March 2020. We identifed a missense mutation, D614G, in the spike protein of SARSCoV-2, which has emerged as a predominant clade in Europe (954 of 1,449 (66%) sequences) and is spreading worldwide (1,237 of 2,795 (44%) sequences). Molecular dating analysis estimated the emergence of this clade around mid-to-late January (10–25 January) 2020. We also applied structural bioinformatics to assess the potential impact of D614G on the virulence and epidemiology of SARSCoV-2. In silico analyses on the spike protein structure suggests that the mutation is most likely neutral to protein function as it relates to its interaction with the human ACE2 receptor. The lack of clinical metadata available prevented our investigation of association between viral clade and disease severity phenotype. Future work that can leverage clinical outcome data with both viral and human genomic diversity is needed to monitor the pandemic.
Palabras clave
SARS‑CoV‑2; D614G; Spike protein
URI
http://hdl.handle.net/20.500.12010/13391
Link to resource
https://doi.org/10.1038/s41598-020-70827-z
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  • Documentos científicos relacionados a la COVID-19 [2292]
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Carrera 4 # 22-61 Teléfono: (+57 1) 242 7030 - 018000111022 Fax: (+57 1) 561 2107 Bogotá D.C., Colombia

Fundación Universitaria de Bogotá Jorge Tadeo Lozano | Vigilada Mineducación

Institución de educación superior privada, de utilidad común, sin ánimo de lucro y su carácter académico es el de Universidad.

Reconocimiento personería jurídica: Resolución 2613 del 14 de agosto de 1959 Minjusticia.

Institución de Educación Superior sujeta a inspección y vigilancia por el Ministerio de Educación Nacional.

 

Términos y condiciones | Políticas