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dc.creatorJeong, Hye Jin
dc.creatorMin, Sein
dc.creatorChae, Heelim
dc.creatorKim, Sarah
dc.creatorLee, Gunwoo
dc.creatorNamgoong, Sung Keon
dc.creatorJeong, Keunhong
dc.date.accessioned2020-09-17T20:12:24Z
dc.date.available2020-09-17T20:12:24Z
dc.date.created2020
dc.identifier.issn2045 2322spa
dc.identifier.otherhttps://doi.org/10.1038/s41598-020-71282-6spa
dc.identifier.urihttp://hdl.handle.net/20.500.12010/13384
dc.description.abstractSeveral drug candidates have been proposed and tested as the latest clinical treatment for coronavirus pneumonia (COVID-19). Chloroquine, hydroxychloroquine, ritonavir/lopinavir, and favipiravir are under trials for the treatment of this disease. The hyperpolarization technique has the ability to further provide a better understanding of the roles of these drugs at the molecular scale and in diferent applications in the feld of nuclear magnetic resonance/magnetic resonance imaging. This technique may provide new opportunities in diagnosis and research of COVID-19. Signal amplifcation by reversible exchange-based hyperpolarization studies on large-sized drug candidates were carried out. We observed hyperpolarized proton signals from whole structures, due to the unprecedented long-distance polarization transfer by para-hydrogen. We also found that the optimal magnetic feld for the maximum polarization transfer yield was dependent on the molecular structure. We can expect further research on the hyperpolarization of other important large molecules, isotope labeling, as well as polarization transfer on nuclei with a long spin relaxation time. A clinical perspective of these features on drug molecules can broaden the application of hyperpolarization techniques for therapeutic studiesspa
dc.format.extent13 Páginasspa
dc.format.mimetypetext/htmlspa
dc.language.isoengspa
dc.publisherScientific reportsspa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectCOVID‑19spa
dc.subjectAntiviral drugsspa
dc.titleSignal amplifcation by reversible exchange for COVID‐19 antiviral drug candidatesspa
dc.type.localArtículospa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.rights.localAbierto (Texto Completo)spa
dc.identifier.doihttps://doi.org/10.1038/s41598-020-71282-6spa
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1spa


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