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dc.creatorBrat, Gabriel A.
dc.creatorWeber, Griffin M.
dc.creatorGehlenborg, Nils
dc.creatorAvillach, Paul
dc.creatorPalmer, Nathan P.
dc.creatorChiovato, Luca
dc.creatorCimino, James
dc.creatorWaitman, Lemuel R.
dc.creatorOmenn, Gilbert S.
dc.creatorMalovini, Alberto
dc.creatorMoore, Jason H.
dc.creatorBeaulieu-Jones, Brett K.
dc.creatorTibollo, Valentina
dc.creatorMurphy, Shawn N.
dc.creatorYi, Sehi L’
dc.creatorKeller, Mark S.
dc.creatorBellazzi, Riccardo
dc.creatorHanauer, David A.
dc.creatorSerret-Larmande, Arnaud
dc.creatorGutierrez-Sacristan, Alba
dc.creatorHolmes, John J.
dc.creatorBell, Douglas S.
dc.creatorMandl, Kenneth D.
dc.creatorFollett, Robert W.
dc.creatorKlann, Jeffrey G.
dc.creatorMurad1, Douglas A.
dc.creatorScudeller, Luigia
dc.creatorBucalo, Mauro
dc.creatorKirchof, Katie
dc.creatorCraig1, Jean
dc.creatorObeid, Jihad
dc.creatorJouhet, Vianney
dc.creatorGriffier, Romain
dc.creatorCossin, Sebastien
dc.creatorMoal, Bertrand
dc.creatorPatel, Lav P.
dc.creatorBellasi, Antonio
dc.creatorProkosch, Hans U.
dc.creatorKraska, Detlef
dc.creatorSliz, Piotr
dc.creatorTan, Amelia L. M.
dc.creatorNgiam, Kee Yuan
dc.creatorZambelli, Alberto
dc.creatorMowery, Danielle L.
dc.creatorSchive, Emily
dc.creatorDevkota, Batsal
dc.creatorBradford, Robert L.
dc.creatorDaniar1, Mohamad
dc.creatorDaniel, Christel
dc.creatorBenoit, Vincent
dc.creatorBey, Romain
dc.creatorParis, Nicolas
dc.creatorSerre, Patricia
dc.creatorOrlova, Nina
dc.creatorDubiel, Julien
dc.creatorHilka, Martin
dc.creatorJannot, Anne Sophie
dc.creatorBreant, Stephane
dc.creatorLeblanc, Judith
dc.creatorGriffon, Nicolas
dc.creatorBurgun, Anita
dc.creatorBernaux, Melodie
dc.creatorSandrin, Arnaud
dc.creatorSalamanca, Elisa
dc.creatorCormont, Sylvie
dc.creatorGanslandt, Thomas
dc.creatorGradinger, Tobias
dc.creatorChamp, Julien
dc.creatorBoeker, Martin
dc.creatorMartel, Patricia
dc.creatorEsteve, Loic
dc.creatorGramfort, Alexandre
dc.creatorGrisel, Olivier
dc.creatorLeprovost, Damien
dc.creatorMoreau, Thomas
dc.creatorVaroquaux, Gael
dc.creatorVie, Jill-Jênn
dc.creatorWassermann, Demian
dc.creatorMensch, Arthur
dc.creatorCaucheteux, Charlotte
dc.creatorHaverkamp, Christian
dc.creatorLemaitre, Guillaume
dc.creatorBosari, Silvano
dc.creatorKrantz, Ian D.
dc.creatorSouth, Andrew
dc.creatorCai, Tianxi
dc.creatorKohane, Isaac S.
dc.date.accessioned2020-09-17T16:26:07Z
dc.date.available2020-09-17T16:26:07Z
dc.date.created2020
dc.identifier.issn2398-6352spa
dc.identifier.otherhttps://doi.org/10.1038/s41746-020-00308-0spa
dc.identifier.urihttp://hdl.handle.net/20.500.12010/13361
dc.description.abstractWe leveraged the largely untapped resource of electronic health record data to address critical clinical and epidemiological questions about Coronavirus Disease 2019 (COVID-19). To do this, we formed an international consortium (4CE) of 96 hospitals across five countries (www.covidclinical.net). Contributors utilized the Informatics for Integrating Biology and the Bedside (i2b2) or Observational Medical Outcomes Partnership (OMOP) platforms to map to a common data model. The group focused on temporal changes in key laboratory test values. Harmonized data were analyzed locally and converted to a shared aggregate form for rapid analysis and visualization of regional differences and global commonalities. Data covered 27,584 COVID-19 cases with 187,802 laboratory tests. Case counts and laboratory trajectories were concordant with existing literature. Laboratory tests at the time of diagnosis showed hospital-level differences equivalent to country-level variation across the consortium partners. Despite the limitations of decentralized data generation, we established a framework to capture the trajectory of COVID-19 disease in patients and their response to interventions.spa
dc.format.extent9 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.publisherDigital medicinespa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectCOVID-19spa
dc.subject4CE consortiumspa
dc.subjectClinical course profilesspa
dc.titleInternational electronic health record-derived COVID-19 clinical course profiles: the 4CE consortiumeng
dc.type.localArtículospa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.rights.localAbierto (Texto Completo)spa
dc.identifier.doihttps://doi.org/10.1038/s41746-020-00308-0spa
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1spa


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