International electronic health record-derived COVID-19 clinical course profiles: the 4CE consortium
Date
2020Author
Brat, Gabriel A.
Weber, Griffin M.
Gehlenborg, Nils
Avillach, Paul
Palmer, Nathan P.
Chiovato, Luca
Cimino, James
Waitman, Lemuel R.
Omenn, Gilbert S.
Malovini, Alberto
Moore, Jason H.
Beaulieu-Jones, Brett K.
Tibollo, Valentina
Murphy, Shawn N.
Yi, Sehi L’
Keller, Mark S.
Bellazzi, Riccardo
Hanauer, David A.
Serret-Larmande, Arnaud
Gutierrez-Sacristan, Alba
Holmes, John J.
Bell, Douglas S.
Mandl, Kenneth D.
Follett, Robert W.
Klann, Jeffrey G.
Murad1, Douglas A.
Scudeller, Luigia
Bucalo, Mauro
Kirchof, Katie
Craig1, Jean
Obeid, Jihad
Jouhet, Vianney
Griffier, Romain
Cossin, Sebastien
Moal, Bertrand
Patel, Lav P.
Bellasi, Antonio
Prokosch, Hans U.
Kraska, Detlef
Sliz, Piotr
Tan, Amelia L. M.
Ngiam, Kee Yuan
Zambelli, Alberto
Mowery, Danielle L.
Schive, Emily
Devkota, Batsal
Bradford, Robert L.
Daniar1, Mohamad
Daniel, Christel
Benoit, Vincent
Bey, Romain
Paris, Nicolas
Serre, Patricia
Orlova, Nina
Dubiel, Julien
Hilka, Martin
Jannot, Anne Sophie
Breant, Stephane
Leblanc, Judith
Griffon, Nicolas
Burgun, Anita
Bernaux, Melodie
Sandrin, Arnaud
Salamanca, Elisa
Cormont, Sylvie
Ganslandt, Thomas
Gradinger, Tobias
Champ, Julien
Boeker, Martin
Martel, Patricia
Esteve, Loic
Gramfort, Alexandre
Grisel, Olivier
Leprovost, Damien
Moreau, Thomas
Varoquaux, Gael
Vie, Jill-Jênn
Wassermann, Demian
Mensch, Arthur
Caucheteux, Charlotte
Haverkamp, Christian
Lemaitre, Guillaume
Bosari, Silvano
Krantz, Ian D.
South, Andrew
Cai, Tianxi
Kohane, Isaac S.
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Abstract
We leveraged the largely untapped resource of electronic health record data to address critical clinical and epidemiological
questions about Coronavirus Disease 2019 (COVID-19). To do this, we formed an international consortium (4CE) of 96 hospitals
across five countries (www.covidclinical.net). Contributors utilized the Informatics for Integrating Biology and the Bedside (i2b2) or
Observational Medical Outcomes Partnership (OMOP) platforms to map to a common data model. The group focused on temporal
changes in key laboratory test values. Harmonized data were analyzed locally and converted to a shared aggregate form for rapid
analysis and visualization of regional differences and global commonalities. Data covered 27,584 COVID-19 cases with 187,802
laboratory tests. Case counts and laboratory trajectories were concordant with existing literature. Laboratory tests at the time of
diagnosis showed hospital-level differences equivalent to country-level variation across the consortium partners. Despite the
limitations of decentralized data generation, we established a framework to capture the trajectory of COVID-19 disease in patients
and their response to interventions.
Palabras clave
COVID-19; 4CE consortium; Clinical course profilesLink to resource
https://doi.org/10.1038/s41746-020-00308-0Collections
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