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dc.creatorRiksen, Niels P.
dc.creatorNetea, Mihai G.
dc.date.accessioned2020-09-15T19:43:38Z
dc.date.available2020-09-15T19:43:38Z
dc.date.created2020
dc.identifier.issn0098-2997spa
dc.identifier.otherhttps://doi.org/10.1016/j.mam.2020.100897spa
dc.identifier.urihttp://hdl.handle.net/20.500.12010/13282
dc.description.abstractInnate immune cells can adopt long-term inflammatory phenotypes following brief encounters with exogenous (microbial) or endogenous stimuli. This phenomenon is named trained immunity and can improve host defense against (recurrent) infections. In contrast, trained immunity can also be maladaptive in the context of chronic inflammatory disorders, such as atherosclerosis. Key to future therapeutic exploitation of this mechanism is thorough knowledge of the mechanisms driving trained immunity, which can be used as pharmacological targets. These mechanisms include profound changes in intracellular metabolism, which are closely intertwined with epigenetic reprogramming at the level of histone modifications. Glycolysis, glutamine replenishment of the tricarboxylic acid cycle with accumulation of fumarate, and the mevalonate pathway have all been identified as critical pathways for trained immunity in monocytes and macrophages. In this review, we provide a state-of-theart overview of how these metabolic pathways interact with epigenetic programs to develop trained immunity.spa
dc.format.extent9 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.publisherMolecular Aspects of Medicinespa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectImmunometabolic controlspa
dc.subjectTrained immunityspa
dc.titleImmunometabolic control of trained immunityspa
dc.type.localArtículospa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.rights.localAbierto (Texto Completo)spa
dc.identifier.doihttps://doi.org/10.1016/j.mam.2020.100897spa
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1spa


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