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dc.creatorSamrat, Subodh Kumar
dc.creatorTharappel, Anil M.
dc.creatorLi, Zhong
dc.creatorLi, Hongmin
dc.date.accessioned2020-09-12T15:21:31Z
dc.date.available2020-09-12T15:21:31Z
dc.date.created2020-10-15
dc.identifier.issn0168-1702spa
dc.identifier.otherhttps://www.sciencedirect.com/science/article/pii/S0168170220310480?via%3Dihubspa
dc.identifier.urihttp://hdl.handle.net/20.500.12010/13212
dc.format.extent17 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.publisherVirus Researchspa
dc.subjectCOVID-19spa
dc.titleProspect of SARS-CoV-2 spike protein: Potential role in vaccine and therapeutic developmentspa
dc.rights.accessrightsinfo:eu-repo/semantics/embargoedAccessspa
dc.rights.localAcceso restringidospa
dc.subject.keywordTherapeuticspa
dc.subject.keywordSARS-CoV-2spa
dc.subject.keywordVaccinespa
dc.subject.keywordSpike proteinspa
dc.identifier.doihttps://doi.org/10.1016/j.virusres.2020.198141spa
dc.description.abstractenglishThe recent outbreak of the betacoronavirus SARS-CoV-2 has become a significant concern to public health care worldwide. As of August 19, 2020, more than 22,140,472 people are infected, and over 781,135 people have died due to this deadly virus. In the USA alone, over 5,482,602 people are currently infected, and more than 171,823 people have died. SARS-CoV-2 has shown a higher infectivity rate and a more extended incubation period as compared to previous coronaviruses. SARS-CoV-2 binds much more strongly than SARS-CoV to the same host receptor, angiotensin-converting enzyme 2 (ACE2). Previously, several methods to develop a vaccine against SARS-CoV or MERS-CoV have been tried with limited success. Since SARS-CoV-2 uses the spike (S) protein for entry to the host cell, it is one of the most preferred targets for making vaccines or therapeutics against SARS-CoV-2. In this review, we have summarised the characteristics of the S protein, as well as the different approaches being used for the development of vaccines and/or therapeutics based on the S protein.spa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa


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