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dc.creatorZheng, Lu
dc.creatorZhang, Lina
dc.creatorHuang, Jiamin
dc.creatorNandakumar, Kutty Selva
dc.creatorLiu, Shuwen
dc.creatorCheng, Kui
dc.date.accessioned2020-09-11T19:53:47Z
dc.date.available2020-09-11T19:53:47Z
dc.date.created2020-11-01
dc.identifier.issn0223-5234spa
dc.identifier.otherhttps://www.sciencedirect.com/science/article/pii/S0223523420306590?via%3Dihubspa
dc.identifier.urihttp://hdl.handle.net/20.500.12010/13178
dc.format.extent31 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.publisherEuropean Journal of Medicinal Chemistryspa
dc.subjectCoronavirusspa
dc.titlePotential treatment methods targeting 2019-nCoV infectionspa
dc.rights.accessrightsinfo:eu-repo/semantics/embargoedAccessspa
dc.rights.localAcceso restringidospa
dc.subject.keywordTarget proteinspa
dc.subject.keywordChemical drugsspa
dc.subject.keywordTraditional Chinese medicine (TCM)spa
dc.subject.keywordVaccinesspa
dc.identifier.doihttps://doi.org/10.1016/j.ejmech.2020.112687spa
dc.description.abstractenglishThe novel coronavirus, 2019-nCoV, has quickly spread across the world and pose serious threat to public health because it can infect people very easily. The major clinical symptoms of 2019-nCoV infection include fever, dry cough, myalgia, fatigue, and diarrhea. The 2019-nCoV belongs to the betacoronavirus family, and gene sequencing results demonstrate that it is a single-stranded RNA virus, closely related to Severe Acute Respiratory Syndrome CoV (SARS-CoV) and Middle East Respiratory Syndrome CoV (MERS-CoV). It has been observed that the virus invades human body mainly through binding to angiotensin-converting enzyme 2 (ACE2) receptors similar to SARS-CoV and the main protease (Mpro) acts as a critical protease for digesting the polyprotein into functional polypeptides during the replication and transcription process of 2019-nCoV. In this review, we summarized the real-time information of 2019-nCoV treatment methods and mainly focused on the chemical drugs including lopinavir/ritonavir, chloroquine, hydroxychloroquine, arbidol, remdesivir, favipiravir and other potential innovative active molecules. Their potential targets, activity, clinical status and side effects are described. In addition, Traditional Chinese Medicine (TCM), Convalescent plasma therapy (CPT) and biological reagents available, as well as the promising vaccine candidates against 2019-nCoV are also discussed.spa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa


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