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dc.creatorWalls, Alexandra C.
dc.creatorPark, Young-Jun
dc.creatorTortorici, M. Alejandra
dc.creatorWall, Abigail
dc.creatorMcGuire, Andrew T.
dc.creatorVeesler, David
dc.date.accessioned2020-09-11T15:49:19Z
dc.date.available2020-09-11T15:49:19Z
dc.date.created2020-04-16
dc.identifier.issn1097-4172spa
dc.identifier.otherhttps://www.cell.com/cell/fulltext/S0092-8674(20)30262-2?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867420302622%3Fshowall%3Dtruespa
dc.identifier.urihttp://hdl.handle.net/20.500.12010/13165
dc.format.extent19 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.publisherCellspa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectspike glycoproteinspa
dc.subjectantibodiesspa
dc.subjectneutralizing antibodiesspa
dc.subjectviral receptorspa
dc.subjectcryo-EMspa
dc.titleStructure, Function, and Antigenicity of the SARS- CoV-2 Spike Glycoproteinspa
dc.type.localArtículospa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.rights.accessrightsinfo:eu-repo/semantics/restrictedAccessspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.rights.localAcceso restringidospa
dc.identifier.doihttps://doi.org/10.1016/j.cell.2020.02.058spa
dc.description.abstractenglishThe emergence of SARS-CoV-2 has resulted in >90,000 infections and >3,000 deaths. Coronavirus spike (S) glycoproteins promote entry into cells and are the main target of antibodies. We show that SARS-CoV-2 S uses ACE2 to enter cells and that the receptor-binding domains of SARS-CoV-2 S and SARS-CoV S bind with similar affinities to human ACE2, correlating with the efficient spread of SARS-CoV-2 among humans. We found that the SARS-CoV-2 S glycoprotein harbors a furin cleavage site at the boundary between the S1/S2 subunits, which is processed during biogenesis and sets this virus apart from SARS-CoV and SARS-related CoVs. We determined cryo-EM structures of the SARS-CoV-2 S ectodomain trimer, providing a blueprint for the design of vaccines and inhibitors of viral entry. Finally, we demonstrate that SARS-CoV S murine polyclonal antibodies potently inhibited SARS-CoV-2 S mediated entry into cells, indicating that cross-neutralizing antibodies targeting conserved S epitopes can be elicited upon vaccination.spa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa


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