Bioactive pyrrole-based compounds with target selectivity
Date
2020Author
Li Petr, Giovanna
Spanò, Virginia
Spatola, Roberto
Holl, Ralph
Raimondi, Maria Valeria
Barraja, Paola
Montalbano, Alessandra
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Abstract
The discovery of novel synthetic compounds with drug-like properties is an ongoing challenge in
medicinal chemistry. Natural products have inspired the synthesis of compounds for pharmaceutical
application, most of which are based on N-heterocyclic motifs. Among these, the pyrrole ring is one
of the most explored heterocycles in drug discovery programs for several therapeutic areas,
confirmed by the high number of pyrrole-based drugs reaching the market. In the present review,
we focused on pyrrole and its hetero-fused derivatives with anticancer, antimicrobial, and antiviral
activities, reported in the literature between 2015 and 2019, for which a specific target was
identified, being responsible for their biological activity. It emerges that the powerful
pharmaceutical and pharmacological features provided by the pyrrole nucleus as pharmacophore
unit of many drugs are still recognized by medicinal chemists.
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https://doi.org/10.1016/j.ejmech.2020.112783Collections
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