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Chemokine receptor gene polymorphisms and COVID-19: Could knowledge gained from HIV/AIDS be important?
dc.creator | Mehlotra, Rajeev K. | |
dc.date.accessioned | 2020-09-07T16:32:33Z | |
dc.date.available | 2020-09-07T16:32:33Z | |
dc.date.created | 2020 | |
dc.identifier.issn | 1567-1348 | spa |
dc.identifier.other | https://doi.org/10.1016/j.meegid.2020.104512 | spa |
dc.identifier.uri | http://hdl.handle.net/20.500.12010/12838 | |
dc.description.abstract | Emerging results indicate that an uncontrolled host immune response, leading to a life-threatening condition called cytokine release syndrome (also termed “cytokine storm”), is the major driver of pathology in severe COVID-19. In this pandemic, considerable effort is being focused on identifying host genomic factors that increase susceptibility or resistance to the complications of COVID-19 and translating these findings to improved patient care. In this regard, the chemokine receptor-ligand nexus has been reported as potentially important in severe COVID-19 disease pathogenesis and its treatment. Valuable genomic insights into the chemokine receptor-ligand nexus have been gained from HIV infection and disease progression studies. Applying that knowledge, together with newly discovered potential host genomic factors associated with COVID-19, may lead to a more comprehensive understanding of the pathogenesis and treatment outcomes in COVID-19 patients. | spa |
dc.format.extent | 5 páginas | spa |
dc.format.mimetype | image/jepg | spa |
dc.language.iso | eng | spa |
dc.publisher | Infection, Genetics and Evolution | spa |
dc.source | reponame:Expeditio Repositorio Institucional UJTL | spa |
dc.source | instname:Universidad de Bogotá Jorge Tadeo Lozano | spa |
dc.subject | CCR5 | spa |
dc.subject | COVID-19 | spa |
dc.subject | HIV/AIDS | spa |
dc.subject | Host genetics | spa |
dc.title | Chemokine receptor gene polymorphisms and COVID-19: Could knowledge gained from HIV/AIDS be important? | spa |
dc.type.local | Artículo | spa |
dc.subject.lemb | Síndrome respiratorio agudo grave | spa |
dc.subject.lemb | COVID-19 | spa |
dc.subject.lemb | SARS-CoV-2 | spa |
dc.subject.lemb | Coronavirus | spa |
dc.rights.accessrights | info:eu-repo/semantics/embargoedAccess | spa |
dc.type.hasversion | info:eu-repo/semantics/acceptedVersion | spa |
dc.rights.local | Acceso restringido | spa |
dc.identifier.doi | https://doi.org/10.1016/j.meegid.2020.104512 | spa |
dc.type.coar | http://purl.org/coar/resource_type/c_2df8fbb1 | spa |