Show simple item record

dc.creatorGoudouris, Ekaterini S.
dc.date.accessioned2020-09-04T19:26:11Z
dc.date.available2020-09-04T19:26:11Z
dc.date.created2020
dc.identifier.issn0021-7557spa
dc.identifier.otherhttps://doi.org/10.1016/j.jped.2020.08.001spa
dc.identifier.urihttp://hdl.handle.net/20.500.12010/12728
dc.description.abstractObjectives: This was a non-systematic review of the literature on the laboratory diagnosis of COVID-19. Data sources: Searches in PubMed and Google Scholar for articles made available in 2020, using the terms diagnosis ¨ OR¨ diagnostic’’ ¨ OR diagnostic ¨ testsOR¨ ¨testsAND ¨ COVID-19 ¨ OR¨ ¨SARS-CoV-2¨in the title. Summary of findings: Tests for the etiological agent identify genetic material of SARS-CoV-2 or humoral responses to it. The gold standard for diagnosis is the identification of viral genome targets by real-time polymerase chain reaction (RT-PCR) in respiratory tract materials during the first week of symptoms. Serological tests should be indicated from the second week of symptoms onwards. A wide range of different tests is available, with variable sensitivity and specificity, most of which require validation. Laboratory tests such as complete blood count, C-reactive protein (CRP), D-dimer, clotting tests, lactic dehydrogenase (LDH), ferritin, and procalcitonin identify risk of disease with greater severity, thromboembolic complications, myocardial damage, and/or worse prognosis. Imaging tests may be useful for diagnosis, especially when there is a compatible clinical picture, and other tests presented negative results or were unavailable. Conclusions: The identification of genetic material of the virus by RT-PCR is the gold standard test, but its sensitivity is not satisfactory. The diagnosis of COVID-19 should be based on clinical data, epidemiological history, tests for etiological diagnosis, and tests to support the diagnosis of the disease and/or its complications. New diagnostic methods with higher sensitivity and specificity, as well as faster results, are necessary. © 2020 Sociedade Brasileira de Pediatria. Published by Elsevier Editora Ltda. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/ 4.0/).spa
dc.format.extent6 páginasspa
dc.format.mimetypetext/htmlspa
dc.language.isoengspa
dc.publisherJornal de pediatriaspa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectDiagnosisspa
dc.subjectDiagnostic testsspa
dc.subjectDiagnostic techniques and proceduresspa
dc.subjectCOVID-19spa
dc.subjectCoronavirusspa
dc.titleLaboratory diagnosis of COVID-19spa
dc.type.localArtículospa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.rights.localAbierto (Texto Completo)spa
dc.identifier.doihttps://doi.org/10.1016/j.jped.2020.08.001spa
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1spa


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record