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dc.creatorMansouri, Kamran
dc.creatorRastegari-Pouyani, Mohsen
dc.creatorGhanbri-Movahed, Maryam
dc.creatorSafarzadeh, Mehrnoush
dc.creatorKiani, Sara
dc.creatorGhanbari-Movahed, Zahra
dc.date.accessioned2020-09-04T18:50:12Z
dc.date.available2020-09-04T18:50:12Z
dc.date.created2020
dc.identifier.issn0753-3322spa
dc.identifier.otherhttps://doi.org/10.1016/j.biopha.2020.110694spa
dc.identifier.urihttp://hdl.handle.net/20.500.12010/12722
dc.description.abstractAs a process entailing a high turnover of the host cell molecules, viral replication is required for a successful viral infection and requests virus capacity to acquire the macromolecules required for its propagation. To this end, viruses have adopted several strategies to harness cellular metabolism in accordance with their specific demands. Most viruses upregulate specific cellular anabolic pathways and are largely dependent on such alterations. RNA viruses, for example, upregulate both glycolysisand glycogenolysis providing TCA cycle intermediates essential for anabolic lipogenesis. Also, these infections usually induce the PPP, leading to increased nucleotide levels supporting viral replication. SARS-CoV-2 (the cause of COVID-19)that has so far spread from China throughout the world is also an RNA virus. Owing to the more metabolic plasticity of uninfected cells, a promising approach for specific antiviral therapy, which has drawn a lot of attention in the recent years, would be the targeting of metabolic changes induced by viruses. In the current review, we first summarize some of virus-induced metabolic adaptations and then based on these information as well as SARS-CoV-2 pathogenesis, propose a potential therapeutic modality for this calamitous world-spreading virus with the hope of employing this strategy for near-future clinical application.spa
dc.format.extent43 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.publisherBiomedicine & Pharmacotherapyspa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectSARS-CoV-2spa
dc.subjectCellular metabolismspa
dc.subjectGlycolysisspa
dc.subjectPPPspa
dc.subjectTCA cyclespa
dc.titleCan a metabolism-targeted therapeutic intervention successfully subjugate coronavirus? A scientific rationalspa
dc.type.localArtículospa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.rights.localAbierto (Texto Completo)spa
dc.identifier.doihttps://doi.org/10.1016/j.biopha.2020.110694spa
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1spa


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