BCG vaccination induced protection from COVID-19
Fecha
2020Autor
Raghab Mohapatra, Prasanta
Mishra, Baijayantimala
Behera, Bijayini
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Resumen
There are worldwide urgency, efforts, and uncertainties for the discovery of a vaccine against
SARS CoV2. If successful, it will take own time till useful for the humans. Till the specific vaccine
available, there are evidences for repurposing existing other vaccine. It is observed that the
countries having routine BCG vaccination programme, had shown to have lower incidence of COVID19, suggesting some protective mechanisms of BCG against COVID-19 in such countries. Countries
like India despite vast population density and other adversities, and growing numbers of COVID19
infections, the mortality rate and severity of COVID has been low in comparison to TB non-endemic
countries (like Europe and USA). In addition, there are evidences that BCG vaccination offers partial
protection and survival in low-income countries where tuberculosis is prevalent. The nonspecific
effects (NSEs) of immune responses induced by BCG vaccination, protect against other infections are
seems to be due to its immunological memory eliciting lymphocytes response and trained immunity.
The protective effect on other viral infection in humans are believed to be mediated by heterologous
lymphocyte activation and the initiation of innate immune memory may be applicable to SARS CoV2.
The BCG vaccination at birth does not have protective effect beyond childhood against COVID-19. In
adult, there might be some other factors dampening the virulence and pathogenicity of COVID-19. In
the TB endemic countries like India, with high population density, similar to BCG vaccination, the
environmental Mycobacteria might be imparting some immune-protection from severity and deaths
of COVID-19.
Palabras clave
BCG vaccination; Protection; COVID-19; Corona virus; Non-tubercular mycobacteriaEnlace al recurso
https://doi.org/10.1016/j.ijtb.2020.08.004Colecciones
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