COVID-19: pharmacology and kinetics of viral clearance
Date
2020Author
Farina, Nicola
Ramirez, Giuseppe A.
De Lorenzo, Rebecca
Di Filippo, Luigi
Conte, Caterina
Ciceri, Fabio
Manfredi, Angelo A.
Rovere-Querini, Patrizia
Metadata
Show full item record
Documentos PDF
Imagenes y Videos
Abstract
Coronavirus Disease 2019 (COVID-19) is a pandemic disease caused by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). The clinical spectrum of COVID-19 is
broad and varies from mild to severe forms complicated by acute respiratory distress and
death. This heterogeneity might reflect the ability of the host immune system to interact
with SARS-CoV2 or the characteristics of the virus itself in terms of loads or persistence.
Information on this issue might derive from interventional studies. However, results from
high-quality trials are scarce. Here we evaluate the level of evidence of available
published interventional studies, with a focus on randomised controlled trials and the
efficacy of therapies on clinical outcomes. Moreover, we present data on a large cohort of
well-characterized patients hospitalized at a single University Hospital in Milano (Italy),
correlating viral clearance with clinical and biochemical features of patients.
Link to resource
https://doi.org/10.1016/j.phrs.2020.105114Collections
Estadísticas Google Analytics
Comments
Respuesta Comentario Repositorio Expeditio
Gracias por tomarse el tiempo para darnos su opinión.