The under-reported role of toxic substance exposures in the COVID-19 pandemic
Fecha
2020Autor
Kostoff, Ronald N.
Briggs, Michael B.
Porter, Alan L.
Hernández, Antonio F.
Abdollahi, Mohammad
Aschner, Michael
Tsatsakis, Aristidis
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Resumen
Coronavirus disease 2019 (COVID-19) and previous pandemics have been viewed almost exclusively as
virology problems, with toxicology problems mostly being ignored. This perspective is not supported by
the evolution of COVID-19, where the impact of real-life exposures to multiple toxic stressors degrading
the immune system is followed by the SARS-CoV-2 virus exploiting the degraded immune system to
trigger a chain of events ultimately leading to COVID-19. This immune system degradation from
multiple toxic stressors (chemical, physical, biological, psychosocial stressors) means that attribution of
serious consequences from COVID-19 should be made to the virus-toxic stressors nexus, not to any of
the nexus constituents in isolation. The leading toxic stressors (identified in this study as contributing to
COVID-19) are pervasive, contributing to myriad chronic diseases as well as immune system
degradation. They increase the likelihood for comorbidities and mortality associated with COVID-19.
For the short-term, tactical/reactive virology-focused treatments are of higher priority than
strategic/proactive toxicology-focused treatments, although both could be implemented in parallel to
reinforce each other. However, for long-term pandemic prevention, toxicology-based approaches
should be given higher priority than virology-based approaches. Since current COVID-19 treatments
globally ignore the toxicology component almost completely, only limited benefits can be expected from
these treatments.
Palabras clave
Toxic substance; COVID-19; PandemicEnlace al recurso
https://doi.org/10.1016/j.fct.2020.111687Colecciones
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