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dc.creatorVarghese, Praveen Mathews
dc.creatorTsolaki, Anthony G.
dc.date.accessioned2020-08-27T17:07:32Z
dc.date.available2020-08-27T17:07:32Z
dc.date.created2020
dc.identifier.issn0171-2985spa
dc.identifier.otherhttps://doi.org/10.1016/j.imbio.2020.152008spa
dc.identifier.urihttp://hdl.handle.net/20.500.12010/12348
dc.description.abstractThe current coronavirus pandemic, COVID-19, is the third outbreak of disease caused by the coronavirus family, after Severe Acute Respiratory Syndrome and Middle East Respiratory Syndrome. It is an acute infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 Virus (SARS-CoV-2). The severe disease is characterised by acute respiratory distress syndrome, septic shock, metabolic acidosis, coagulation dysfunction, and multiple organ dysfunction syndromes. Currently, no drugs or vaccine exist against the disease and the only course of treatment is symptom management involving mechanical ventilation, immune suppressants, and repurposed drugs. As such the severe form of the disease has a relatively high mortality rate. Last 6 months have seen an explosion of information related to the host receptors, virus transmission, virus structure-function relationships, pathophysiology, comorbidities, immune response, treatment and most promising vaccines. This review takes a critically comprehensive look at various aspects of host-pathogen interaction in COVID-19. We examine genomic aspects of SARS-CoV-2, modulation of innate and adaptive immunity, complement-triggered microangiopathy, and host transmission modalities. We also examine its pathophysiological impact during pregnancy, in addition to various gaps in our knowledge. The lessons learnt from various clinical trials involving repurposed drugs have been summarised. We also highlight the rationale and likely success of the most promising vaccine candidates.spa
dc.format.extent70 páginasspa
dc.format.mimetypeimage/jepgspa
dc.language.isoengspa
dc.publisherImmunobiologyspa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectCOVID-19spa
dc.subjectSARS-CoV-2spa
dc.subjectLife-cyclespa
dc.subjectPathophysiologyspa
dc.subjectCo-morbiditiesspa
dc.subjectPregnancyspa
dc.subjectVaccinespa
dc.subjectAnti-viralsspa
dc.titleHost-pathogen interaction in COVID-19: Pathogenesis, potential therapeutics and vaccination strategiesspa
dc.type.localArtículospa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.rights.accessrightsinfo:eu-repo/semantics/embargoedAccessspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.rights.localAcceso restringidospa
dc.identifier.doihttps://doi.org/10.1016/j.imbio.2020.152008spa
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1spa


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