Host-pathogen interaction in COVID-19: Pathogenesis, potential therapeutics and vaccination strategies
Documentos PDF
Imagenes y Videos
Resumo
The current coronavirus pandemic, COVID-19, is the third outbreak of disease caused by the
coronavirus family, after Severe Acute Respiratory Syndrome and Middle East Respiratory
Syndrome. It is an acute infectious disease caused by Severe Acute Respiratory Syndrome
Coronavirus 2 Virus (SARS-CoV-2). The severe disease is characterised by acute respiratory
distress syndrome, septic shock, metabolic acidosis, coagulation dysfunction, and multiple
organ dysfunction syndromes. Currently, no drugs or vaccine exist against the disease and the
only course of treatment is symptom management involving mechanical ventilation, immune
suppressants, and repurposed drugs. As such the severe form of the disease has a relatively
high mortality rate. Last 6 months have seen an explosion of information related to the host
receptors, virus transmission, virus structure-function relationships, pathophysiology, comorbidities, immune response, treatment and most promising vaccines. This review takes a
critically comprehensive look at various aspects of host-pathogen interaction in COVID-19.
We examine genomic aspects of SARS-CoV-2, modulation of innate and adaptive immunity, complement-triggered microangiopathy, and host transmission modalities. We also examine
its pathophysiological impact during pregnancy, in addition to various gaps in our knowledge.
The lessons learnt from various clinical trials involving repurposed drugs have been
summarised. We also highlight the rationale and likely success of the most promising vaccine
candidates.
Palabras clave
COVID-19; SARS-CoV-2; Life-cycle; Pathophysiology; Co-morbidities; Pregnancy; Vaccine; Anti-viralsLink para o recurso
https://doi.org/10.1016/j.imbio.2020.152008Collections
Estadísticas Google Analytics
Comments
Respuesta Comentario Repositorio Expeditio
Gracias por tomarse el tiempo para darnos su opinión.