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dc.creatorMaruthamuthu, Murali K.
dc.creatorRudge, Scott R.
dc.creatorArdekani, Arezoo M.
dc.creatorLadisch, Michael R.
dc.creatorVerma, Mohit S.
dc.date.accessioned2020-08-26T16:55:04Z
dc.date.available2020-08-26T16:55:04Z
dc.date.created2020
dc.identifier.issn1879-3096spa
dc.identifier.otherhttps://doi.org/10.1016/j.tibtech.2020.07.004spa
dc.identifier.urihttp://hdl.handle.net/20.500.12010/12321
dc.description.abstractProcess analytical technology (PAT) for the manufacture of monoclonal antibodies (mAbs) is defined by an integrated set of advanced and automated methods that analyze the compositions and biophysical properties of cell culture fluids, cellfree product streams, and biotherapeutic molecules that are ultimately formulated into concentrated products. In-line or near-line probes and systems are remarkably well developed, although challenges remain in the determination of the absence of viral loads, detecting microbial or mycoplasma contamination, and applying datadriven deep learning to process monitoring and soft sensors. In this review, we address the current status of PAT for both batch and continuous processing steps and discuss its potential impact on facilitating the continuous manufacture of biotherapeutics.spa
dc.format.extent18 páginasspa
dc.format.mimetypeimage/jepgspa
dc.language.isoengspa
dc.publisherTrends in Biotechnologyspa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectSpectrometryspa
dc.subjectSpectroscopyspa
dc.subjectSensorsspa
dc.subjectProcess analytical technologyspa
dc.subjectMonoclonal antibodiesspa
dc.subjectContinuous manufacturingspa
dc.titleProcess analytical technologies and data analytics for the manufacture of monoclonal antibodiesspa
dc.type.localArtículospa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.rights.accessrightsinfo:eu-repo/semantics/embargoedAccessspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.rights.localAcceso restringidospa
dc.identifier.doihttps://doi.org/10.1016/j.tibtech.2020.07.004spa
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1spa


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