Nigella sativa l. as a potential phytotherapy for covid-19: A mini-review of in-silico studies
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Resumo
Background
Coronaviruses are responsible for several human diseases such as the pandemic infectious
disease 2019 (COVID-19) which is caused by the Severe Acute Respiratory Syndrome
Coronavirus 2 (SARS-CoV-2). Nigella sativa (NS) is a natural food supplement with a known
safety profile that may provide a wealth of known antiviral compounds.
Objective
To explore the studies supporting the NS potential for hitting SARS-CoV-2 targets.
Methods A literature search for scientific published or preprint in-silico studies between 1990 and 2020 in
electronic databases (PubMed, Science Direct, Scopus, and Google Scholar) was performed for
the terms Nigella sativa, black seed, coronavirus, SARS-CoV-2 and COVID-19.
Results
At least eight in-silico studies have shown that some compounds of NS, including Nigelledine,
α-Hederin, Hederagenin, Thymohydroquinone, and Thymoquinone, had high to moderate
affinity with SARS-CoV-2 enzymes and proteins. These compounds may potentially inhibit
SARS-CoV-2 replication and attachment to host cell receptors.
Conclusions
These preliminary data propose NS as a potential phytotherapy candidate for COVID-19. Further
preclinical experimental evidence is required followed by a phase 1 clinical trial.
Keywords: SARS-CoV-2; COVID-19; Coronavirus; In-silico; Nigella sativa
Running Title: Nigella sativa in COVID-19
Palabras clave
COVID-19; Potential phytotherapyLink para o recurso
https://doi.org/10.1016/j.curtheres.2020.100602Collections
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