Development and clinical application of phosphorus-containing drugs
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Abstract
Phosphorus-containing drugs belong to an important class of therapeutic agents and are widely applied in daily clinical
practices. Structurally, the phosphorus-containing drugs can be classified into phosphotriesters, phosphonates, phosphinates,
phosphine oxides, phosphoric amides, bisphosphonates, phosphoric anhydrides, and others; functionally, they are often
designed as prodrugs with improved selectivity and bioavailability, reduced side effects and toxicity, or biomolecule analogues
with endogenous materials and antagonistic endoenzyme supplements. This review summarized the phosphorus-containing
drugs currently on the market as well as a few promising molecules at clinical studies, with particular emphasis on their
structural features, biological mechanism, and indications.
Palabras clave
Phosphorus-containing drugs; Prodrugs; Drug modification; Phosphite, phosphateLink to resource
https://doi.org/10.1016/j.medidd.2020.100063Collections
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