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dc.creatorHamizi, Kamel
dc.creatorAouidane, Souhila
dc.creatorBelaaloui, Ghania
dc.date.accessioned2020-08-21T17:04:34Z
dc.date.available2020-08-21T17:04:34Z
dc.date.created2020
dc.identifier.issn0306-9877spa
dc.identifier.otherhttps://doi.org/10.1016/j.mehy.2020.109826spa
dc.identifier.urihttp://hdl.handle.net/20.500.12010/12096
dc.description.abstractThe new coronavirus infection COVID-19 has quickly become a global health emergency. Mortality is principally due to severe Acute Respiratory Distress Syndrome (ARDS) which relays only on supportive treatment. Numerous pathological, clinical and laboratory findings rise the similarity between moderate to severe COVID19 and haemophagocytic lymphohistiocytosis (HLH). Etoposide-based protocol including dexametasone is the standard of care for secondary HLH. The protocol has been successfully used in HLHs that are secondary to EBV and H1N1 infections by inducing complete response and prolonged survival. These observations prompt to consider this cytotoxic therapy in HLH associated to moderately severe to severe forms of COVID-19.spa
dc.format.extent3 páginasspa
dc.format.mimetypeimage/jepgspa
dc.language.isoengspa
dc.publisherMedical Hypothesesspa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectCOVID-19spa
dc.subjectHaemophagocytic lymphohistiocytosisspa
dc.subjectHLHspa
dc.subjectEtoposidespa
dc.titleEtoposide-based therapy for severe forms of COVID-19spa
dc.type.localArtículospa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.rights.accessrightsinfo:eu-repo/semantics/embargoedAccessspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.rights.localAcceso restringidospa
dc.identifier.doihttps://doi.org/10.1016/j.mehy.2020.109826spa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa


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