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dc.creatorEgbert, Anna Rita
dc.creatorCankurtaran, Sadiye
dc.creatorKarpiak, Stephen
dc.date.accessioned2020-08-21T01:34:55Z
dc.date.available2020-08-21T01:34:55Z
dc.date.created2020-07-17
dc.identifier.issn0889-1591spa
dc.identifier.otherhttps://www.sciencedirect.com/science/article/pii/S0889159120312538spa
dc.identifier.urihttp://hdl.handle.net/20.500.12010/12056
dc.format.extent12 Páginasspa
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.publisherBrain, Behavior, and Immunityspa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectCOVID-19spa
dc.titleBrain abnormalities in COVID-19 acute/subacute phase: A rapid systematic reviewspa
dc.type.localArtículospa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.rights.accessrightsinfo:eu-repo/semantics/embargoedAccessspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.rights.localAcceso restringidospa
dc.subject.keywordCNSspa
dc.subject.keywordNeurologicspa
dc.subject.keywordLeukoencephalopathyspa
dc.subject.keywordLeukoaraiosisspa
dc.subject.keywordMicroangiopathyspa
dc.subject.keywordCOVID-19spa
dc.subject.keywordSARS-Cov-2spa
dc.subject.keywordInfectionspa
dc.identifier.doihttps://doi.org/10.1016/j.bbi.2020.07.014spa
dc.description.abstractenglishObjective This systematic review aimed to synthesize early data on typology and topography of brain abnormalities in adults with COVID-19 in acute/subacute phase. Methods We performed systematic literature search via PubMed, Google Scholar and ScienceDirect on articles published between January 1 and July 05, 2020, using the following strategy and key words: ((covid[Title/Abstract]) OR (sars-cov-2[Title/Abstract]) OR (coronavirus[Title/Abstract])) AND (brain[Title/Abstract]). A total of 286 non-duplicate matches were screened for original contributions reporting brain imaging data related to SARS-Cov-2 presentation in adults. Results The selection criteria were met by 26 articles (including 21 case reports, and 5 cohort studies). The data analysis in a total of 361 patients revealed that brain abnormalities were noted in 124/361 (34%) reviewed cases. Neurologic symptoms were the primary reason for referral for neuroimaging across the studies. Modalities included CT (-angiogram, -perfusion, -venogram), EEG, MRI (-angiogram, functional), and PET. The most frequently reported brain abnormalities were brain white matter (WM) hyperintensities on MRI 66/124 (53% affected cases) and hypodensities on CT (additional 23% affected cases), followed by microhemorrhages, hemorrhages and infarcts, while other types were found in <5% affected cases. WM abnormalities were most frequently noted in bilateral anterior and posterior cerebral WM (50% affected cases). Conclusion About a third of acute/subacute COVID-19 patients referred for neuroimaging show brain abnormalities suggestive of COVID-19-related etiology. The predominant neuroimaging features were diffuse cerebral WM hypodensities / hyperintensities attributable to leukoencephalopathy, leukoaraiosis or rarefield WM.spa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa


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