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dc.creatorTavares, Luciana P.
dc.creatorNegreiros-Lima, Graziele L.
dc.creatorLima, Kátia M.
dc.creatorE Silva, Patrícia M.R.
dc.creatorPinho, Vanessa
dc.creatorTeixeira, Mauro M.
dc.creatorSousa, Lirlândia P.
dc.date.accessioned2020-08-21T01:16:37Z
dc.date.available2020-08-21T01:16:37Z
dc.date.created2020-09
dc.identifier.issn1043-6618spa
dc.identifier.otherhttps://www.sciencedirect.com/science/article/abs/pii/S1043661820313384spa
dc.identifier.urihttp://hdl.handle.net/20.500.12010/12055
dc.format.extent12 Páginasspa
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.publisherPharmacological Researchspa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectCOVID-19spa
dc.titleBlame the signaling: Role of cAMP for the resolution of inflammationspa
dc.type.localArtículospa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.rights.accessrightsinfo:eu-repo/semantics/embargoedAccessspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.rights.localAcceso restringidospa
dc.subject.keywordResolution pharmacologyspa
dc.subject.keywordcAMPspa
dc.subject.keywordPhosphodiesterase 4spa
dc.subject.keywordInflammationspa
dc.subject.keywordPro-resolving mediatorsspa
dc.identifier.doihttps://doi.org/10.1016/j.phrs.2020.105030spa
dc.description.abstractenglishA complex intracellular signaling governs different cellular responses in inflammation. Extracellular stimuli are sensed, amplified, and transduced through a dynamic cellular network of messengers converting the first signal into a proper response: production of specific mediators, cell activation, survival, or death. Several overlapping pathways are coordinated to ensure specific and timely induction of inflammation to neutralize potential harms to the tissue. Ideally, the inflammatory response must be controlled and self-limited. Resolution of inflammation is an active process that culminates with termination of inflammation and restoration of tissue homeostasis. Comparably to the onset of inflammation, resolution responses are triggered by coordinated intracellular signaling pathways that transduce the message to the nucleus. However, the key messengers and pathways involved in signaling transduction for resolution are still poorly understood in comparison to the inflammatory network. cAMP has long been recognized as an inducer of anti-inflammatory responses and cAMP-dependent pathways have been extensively exploited pharmacologically to treat inflammatory diseases. Recently, cAMP has been pointed out as coordinator of key steps of resolution of inflammation. Here, we summarize the evidence for the role of cAMP at inducing important features of resolution of inflammation.spa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa


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