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Anti-malarial drug, artemisinin and its derivatives for the treatment of respiratory diseases

dc.creatorCheong, Dorothy H.J.
dc.creatorTan, Daniel W.S.
dc.creatorWong, Fred W.S.
dc.creatorTran, Thai
dc.date.accessioned2020-08-20T16:02:27Z
dc.date.available2020-08-20T16:02:27Z
dc.date.created2020-08
dc.identifier.issn1043-6618spa
dc.identifier.otherhttps://www.sciencedirect.com/science/article/pii/S1043661820312093?via%3Dihub#kwd0010spa
dc.identifier.urihttp://hdl.handle.net/20.500.12010/12016
dc.format.extent15 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.publisherPharmacological Researchspa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectEnfermedades respiratoriasspa
dc.titleAnti-malarial drug, artemisinin and its derivatives for the treatment of respiratory diseasesspa
dc.type.localArtículospa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.subject.lembArtemisininspa
dc.rights.accessrightsinfo:eu-repo/semantics/embargoedAccessspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.rights.localAcceso restringidospa
dc.subject.keywordRespiratory diseasesspa
dc.subject.keywordLungspa
dc.subject.keywordCell proliferationspa
dc.subject.keywordInflammationspa
dc.subject.keywordChemical compounds studied in this article Artemisinin (PubChem CID: 68827)spa
dc.subject.keywordDihydroartemisinin (PubChem CID: 139073990)spa
dc.subject.keywordArtesunate (PubChem CID:156252)spa
dc.subject.keywordArtemisitene (PubChem CID: 11000442)spa
dc.subject.keywordArtemether (PubChem CID: 68911)spa
dc.subject.keywordArteether (PubChem CID: 3000469)spa
dc.identifier.doihttps://doi.org/10.1016/j.phrs.2020.104901spa
dc.description.abstractenglishArtemisinins are sesquiterpene lactones with a peroxide moiety that are isolated from the herb Artemisia annua. It has been used for centuries for the treatment of fever and chills, and has been recently approved for the treatment of malaria due to its endoperoxidase properties. Progressively, research has found that artemisinins displayed multiple pharmacological actions against inflammation, viral infections, and cell and tumour proliferation, making it effective against diseases. Moreover, it has displayed a relatively safe toxicity profile. The use of artemisinins against different respiratory diseases has been investigated in lung cancer models and inflammatory-driven respiratory disorders. These studies revealed the ability of artemisinins in attenuating proliferation, inflammation, invasion, and metastasis, and in inducing apoptosis. Artemisinins can regulate the expression of pro-inflammatory cytokines, nuclear factor-kappa B (NF-κB), matrix metalloproteinases (MMPs), vascular endothelial growth factor (VEGF), promote cell cycle arrest, drive reactive oxygen species (ROS) production and induce Bak or Bax-dependent or independent apoptosis. In this review, we aim to provide a comprehensive update of the current knowledge of the effects of artemisinins in relation to respiratory diseases to identify gaps that need to be filled in the course of repurposing artemisinins for the treatment of respiratory diseases. In addition, we postulate whether artemisinins can also be repurposed for the treatment of COVID-19 given its anti-viral and anti-inflammatory properties.spa


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