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dc.creatorMukherjee, Shruti
dc.creatorBhattacharyya, Dipita
dc.creatorBhunia, Anirban
dc.date.accessioned2020-08-19T15:22:57Z
dc.date.available2020-08-19T15:22:57Z
dc.date.created2020
dc.identifier.issn0301-4622spa
dc.identifier.otherhttps://doi.org/10.1016/j.bpc.2020.106452spa
dc.identifier.urihttp://hdl.handle.net/20.500.12010/11964
dc.description.abstracthe Envelope (E) protein in SARS Coronavirus (CoV) is a small structural protein, incorporated as part of the envelope. A major fraction of the protein has been known to be associated with the host membranes, particularly organelles related to intracellular trafficking, prompting CoV packaging and propagation. Studies have elucidated the central hydrophobic transmembrane domain of the E protein being responsible for much of the viroporin activity in favor of the virus. However, newer insights into the organizational principles at the membranous compartments within the host cells suggest further complexity of the system. The lesser hydrophobic Carboxylic-terminal of the protein harbors interesting amino acid sequences- suggesting at the prevalence of membrane-directed amyloidogenic properties that remains mostly elusive. These highly conserved segments indicate at several potential membrane-associated functional roles that can redefine our comprehensive understanding of the protein. This should prompt further studies in designing and characterizing of effective targeted therapeutic measurespa
dc.format.extent30 páginasspa
dc.format.mimetypeimage/jepgspa
dc.publisherBiophysical Chemistryspa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectSARS CoVspa
dc.subjectE proteinspa
dc.subjectMembranespa
dc.subjectStructurespa
dc.subjectCovid-19spa
dc.subjectAmyloidogenesisspa
dc.titleHost-membrane interacting interface of the SARS coronavirus envelope protein: Immense functional potential of C-terminal domainspa
dc.type.localArtículospa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.rights.accessrightsinfo:eu-repo/semantics/embargoedAccessspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.rights.localAcceso restringidospa
dc.identifier.doihttps://doi.org/10.1016/j.bpc.2020.106452spa


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