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dc.creatorZhang, Jia-Li
dc.creatorLi, Wen-Xiong
dc.creatorLi, Yue
dc.creatorWong, Man-Sau
dc.creatorWang, Yong-Jun
dc.creatorZhang, Yan
dc.date.accessioned2020-08-18T15:51:26Z
dc.date.available2020-08-18T15:51:26Z
dc.date.created2020
dc.identifier.issn0944-7113spa
dc.identifier.otherhttps://doi.org/10.1016/j.phymed.2020.153297spa
dc.identifier.urihttp://hdl.handle.net/20.500.12010/11918
dc.description.abstractBackground: Coronavirus disease-2019 (COVID-19) caused by infection with severe acute respiratory coronavirus-2 (SARS-CoV-2) has been spreading rapidly throughout China and in other countries since the end of 2019. The World Health Organization (WHO) has declared that the epidemic is a public health emergency of international concerns. The timely and appropriate measures for treating COVID-19 in China, which are inseparable from the contribution of traditional Chinese medicine (TCM), have won much praise of the world. Purpose: This review aimed to summarize and discuss the essential role of TCM in protecting tissues from injuries associated with COVID-19, and accordingly to clarify the possible action mechanisms of TCM from the perspectives of anti-inflammatory, antioxidant and anti-apoptotic effects. Methods: Electronic databases such as Pubmed, ResearchGate, Science Direct, Web of Science, medRixv and Wiley were used to search scientific literatures. Results: The present review found that traditional Chinese herbs commonly used for the clinical treatment of organ damages caused by COVID-19, such as Scutellaria baicalensis, Salvia miltiorrhiza, and ginseng, could act on multiple signaling pathways involved in inflammation, oxidative stress and apoptosis. Conclusion: TCM could protect COVID-19 patients from tissue injuries, a protection that might be, at least partially, attributed to the anti-inflammatory, antioxidant and anti-apoptotic effects of the TCM under investigation. This review provides evidence and support for clinical treatment and novel drug research using TCMspa
dc.format.extent32 páginasspa
dc.format.mimetypeimage/jepgspa
dc.publisherPhytomedicinespa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectCoronavirus disease 2019spa
dc.subjectSevere acute respiratory coronavirus-2spa
dc.subjectTraditional Chinese medicinespa
dc.subjectActive componentspa
dc.subjectPharmacological mechanismspa
dc.subjectSignaling pathwayspa
dc.titleTherapeutic options of TCM for organ injuries associated with COVID-19 and the underlying mechanismspa
dc.type.localArtículospa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.rights.accessrightsinfo:eu-repo/semantics/embargoedAccessspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.rights.localAcceso restringidospa
dc.identifier.doihttps://doi.org/10.1016/j.phymed.2020.153297spa


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