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dc.creatorMcCullough, Peter A.
dc.creatorKelly, Ronan J.
dc.creatorRuocco, Gaetano
dc.creatorLerma, Edgar
dc.creatorTumlin, James
dc.creatorWheelan, Kevin
dc.creatorKatz, Nevin
dc.creatorLepor, Norman E.
dc.creatorVijay, Kris
dc.creatorCarter, Harvey
dc.creatorSingh, Bhupinder
dc.creatorMcCullough, Sean P.
dc.creatorBhambi, Brijesh K.
dc.creatorPalazzuoli, Alberto
dc.creatorDe Ferrar, Gaetano M
dc.creatorMilligan, Gregory
dc.creatorSafder, Taimur
dc.creatorTecson, Kristen M.
dc.creatorWang, Dee Dee
dc.creatorMcKinnon
dc.creatorO’Neill, William W.
dc.creatorZervos, Marcus
dc.creatorRisch, Harvey A.
dc.date.accessioned2020-08-18T13:59:41Z
dc.date.available2020-08-18T13:59:41Z
dc.date.created2020
dc.identifier.issnThe American Journal of Medicinespa
dc.identifier.otherhttps://doi.org/10.1016/j.amjmed.2020.07.003spa
dc.identifier.urihttp://hdl.handle.net/20.500.12010/11906
dc.description.abstractApproximately 9 months of the SARS-CoV-2 virus spreading across the globe has led to widespread COVID-19 acute hospitalizations and death. The rapidity and highly communicable nature of the SARS-CoV-2 outbreak has hampered the design and execution of definitive randomized, controlled trials of therapy outside of the clinic or hospital. In the absence of clinical trial results, physicians must use what has been learned about the pathophysiology of SARS-CoV-2 infection in determining early outpatient treatment of the illness with the aim of preventing hospitalization or death. This paper outlines key pathophysiological principles that relate to the patient with early infection treated at home. Therapeutic approaches based on these principles include: 1) reduction of reinoculation, 2) combination antiviral therapy, 3) immunomodulation, 4) antiplatelet/antithrombotic therapy 5) administration of oxygen, monitoring, and telemedicine. Future randomized trials testing the principles and agents discussed in this paper will undoubtedly refine and clarify their individual roles, however we emphasize the immediate need for management guidance in the setting of widespread hospital resource consumption, morbidity, and mortality.spa
dc.format.extent25 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.publisherThe American Journal of Medicinespa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectSARS-CoV-2spa
dc.subjectCOVID-19spa
dc.subjectHospitalizationspa
dc.subjectCritical carespa
dc.subjectMortalityspa
dc.subjectEpidemiologyspa
dc.subjectAmbulatory treatmentspa
dc.subjectAntiviralspa
dc.subjectAnti-inflammatoryspa
dc.subjectAnticoagulantspa
dc.titlePathophysiological basis and rationale for early outpatient treatment of SARS-CoV-2 (COVID-19) Infectionspa
dc.type.localArtículospa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.rights.localAbierto (Texto Completo)spa
dc.identifier.doihttps://doi.org/10.1016/j.amjmed.2020.07.003spa


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