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dc.creatorJutzeler, Catherine R.
dc.creatorBourguignon, Lucie
dc.creatorWeis, Caroline V.
dc.creatorTong, Bobo
dc.creatorWong, Cyrus
dc.creatorRieck, Bastian
dc.creatorPargger, Hans
dc.creatorTschudin-Sutter, Sarah
dc.creatorEgli, Adrin
dc.creatorBorgwardt, Karsten
dc.creatorWalter, Matthias
dc.date.accessioned2020-08-12T17:16:35Z
dc.date.available2020-08-12T17:16:35Z
dc.date.created2020
dc.identifier.issn1477-8939spa
dc.identifier.otherhttps://doi.org/10.1016/j.tmaid.2020.101825spa
dc.identifier.urihttp://hdl.handle.net/20.500.12010/11883
dc.description.abstractIntroduction Since December 2019, a novel coronavirus (SARS-CoV-2) has triggered a world-wide pandemic with an enormous medical and societal-economic toll. Thus, our aim was to gather all available information regarding comorbidities, clinical signs and symptoms, outcomes, laboratory findings, imaging features, and treatments in patients with coronavirus disease 2019 (COVID-19). Methods EMBASE, PubMed/ Medline, Scopus, and Web of Science were searched for studies published in any language between December 1st, 2019 and March 28th. Original studies were included if the exposure of interest was an infection with SARS-CoV-2 or confirmed COVID-19. The primary outcome was the risk ratio of comorbidities, clinical signs and symptoms, imaging features, treatments, outcomes, and complications associated with COVID-19 morbidity and mortality. We performed random-effects pairwise meta-analyses for proportions and relative risks, I 2 , Tau2 , and Cochrane Q, sensitivity analyses, and assessed publication bias. Results: 148 studies met the inclusion criteria for the systematic review and meta-analysis with 12’149 patients (5’739 female) and a median age of 47.0 [35.0-64.6] years. 617 patients died from COVID-19 and its complication. 297 patients were reported as asymptomatic. Older age (SMD: 1.25 [0.78- 1.72]; p < 0.001), being male (RR = 1.32 [1.13-1.54], p = 0.005) and pre-existing comorbidity (RR = 1.69 [1.48-1.94]; p < 0.001) were identified as risk factors of in-hospital mortality. The heterogeneity between studies varied substantially (I 2 ; range: 1.5-98.2%). Publication bias was only found in eight studies (Egger’s test: p < 0.05). Conclusions: Our meta-analyses revealed important risk factors that are associated with severity and mortality of COVID-19.spa
dc.format.extent106 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.publisherTravel Medicine and Infectious Diseasespa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectSARS-CoV-2spa
dc.subjectCOVID-19spa
dc.subjectMeta-analysisspa
dc.subjectSystematic reviewspa
dc.subjectComorbiditiesspa
dc.subjectClinical characteristicsspa
dc.subjectLaboratory findingsspa
dc.subjectImaging featuresspa
dc.subjectTreatmentspa
dc.titleComorbidities, clinical signs and symptoms, laboratory findings, imaging features, treatment strategies, and outcomes in adult and pediatric patients with COVID-19: A systematic review and meta-analysisspa
dc.type.localArtículospa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.rights.localAbierto (Texto Completo)spa
dc.identifier.doihttps://doi.org/10.1016/j.tmaid.2020.101825spa


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