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dc.creatorDomingo, Pere
dc.creatorMur, Isabel
dc.creatorPomar, Virginia
dc.creatorCorominas, Hector
dc.creatorCasademont, Jordi
dc.creatorBenito, Natividad de
dc.date.accessioned2020-08-12T14:54:02Z
dc.date.available2020-08-12T14:54:02Z
dc.date.created2020
dc.identifier.issn2352-3964spa
dc.identifier.otherhttps://doi.org/10.1016/j.ebiom.2020.102887spa
dc.identifier.urihttp://hdl.handle.net/20.500.12010/11862
dc.description.abstractThe pathogenesis of coronavirus disease 2019 (COVID-19) may be envisaged as the dynamic interaction between four vicious feedback loops chained or happening at once. These are the viral loop, the hyperinflammatory loop, the non-canonical renin-angiotensin system (RAS) axis loop, and the hypercoagulation loop. Severe acute respiratory syndrome (SARS)-coronavirus (CoV)-2 lights the wick by infecting alveolar epithelial cells (AECs) and downregulating the angiotensin converting enzyme-2 (ACE2)/angiotensin (Ang-1 7)/ Mas1R axis. The viral feedback loop includes evading the host’s innate response, uncontrolled viral replication, and turning on a hyperactive adaptative immune response. The inflammatory loop is composed of the exuberant inflammatory response feeding back until exploding in an actual cytokine storm. Downregulation of the ACE2/Ang-(1 7)/Mas1R axis leaves the lung without a critical defense mechanism and turns the scale to the inflammatory side of the RAS. The coagulation loop is a hypercoagulable state caused by the interplay between inflammation and coagulation in an endless feedback loop. The result is a hyperinflammatory and hypercoagulable state producing acute immune-mediated lung injury and eventually, adult respiratory distress syndrome.spa
dc.format.extent12 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.publisherEBioMedicinespa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectCOVID-19spa
dc.subjectSARS-CoV-2spa
dc.subjectACE2spa
dc.subjectRASspa
dc.subjectHyperinflammatory statespa
dc.subjectHypercoagulabilityspa
dc.subjectAcute lung injuryspa
dc.subjectAdult distress respiratory syndromespa
dc.titleThe four horsemen of a viral Apocalypse: The pathogenesis of SARS-CoV-2 infection (COVID-19)spa
dc.type.localArtículospa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.rights.localAbierto (Texto Completo)spa
dc.identifier.doihttps://doi.org/10.1016/j.ebiom.2020.102887spa


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