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dc.creatorZhang, Xue
dc.creatorYu, Jiong
dc.creatorPan, Li ya
dc.creatorJiang, Hai yin
dc.date.accessioned2020-08-06T21:22:26Z
dc.date.available2020-08-06T21:22:26Z
dc.date.created2020-08
dc.identifier.issn1043-6618spa
dc.identifier.otherhttps://www.sciencedirect.com/science/article/pii/S1043661820312354?via%3Dihubspa
dc.identifier.urihttp://hdl.handle.net/20.500.12010/11720
dc.format.extent7 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.publisherPharmacological Researchspa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectAntihipertensivospa
dc.subjectHipertensiónspa
dc.titleACEI/ARB use and risk of infection or severity or mortality of COVID-19: A systematic review and meta-analysisspa
dc.type.localArtículospa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.rights.accessrightsinfo:eu-repo/semantics/embargoedAccessspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.rights.localAcceso restringidospa
dc.subject.keywordAntihypertensivespa
dc.subject.keywordHypertensionspa
dc.subject.keywordSystematic reviewspa
dc.subject.keywordMeta-analysisspa
dc.identifier.doihttps://doi.org/10.1016/j.phrs.2020.104927spa
dc.description.abstractenglishThe effects of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) on the risk of COVID-19 infection and disease progression are yet to be investigated. The relationship between ACEI/ARB use and COVID-19 infection was systematically reviewed. To identify relevant studies that met predetermined inclusion criteria, unrestricted searches of the PubMed, Embase, and Cochrane Library databases were conducted. The search strategy included clinical date published until May 9, 2020. Twelve articles involving more than 19,000 COVID-19 cases were included. To estimate overall risk, random-effects models were adopted. Our results showed that ACEI/ARB exposure was not associated with a higher risk of COVID-19 infection (OR = 0.99; 95 % CI, 0–1.04; P = 0.672). Among those with COVID-19 infection, ACEI/ARB exposure was also not associated with a higher risk of having severe infection (OR = 0.98; 95 % CI, 0.87–1.09; P = 0.69) or mortality (OR = 0.73, 95 %CI, 0.5–1.07; P = 0.111). However, ACEI/ARB exposure was associated with a lower risk of mortality compared to those on non-ACEI/ARB antihypertensive drugs (OR = 0.48, 95 % CI, 0.29−0.81; P = 0.006). In conclusion, current evidence did not confirm the concern that ACEI/ARB exposure is harmful in patientswith COVID-19 infection. This study supports the current guidelines that discourage discontinuation of ACEIs or ARBs in COVID-19 patients and the setting of the COVID-19 pandemic.spa


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