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dc.creatorKermali, Muhammed
dc.creatorKaur Khalsa, Raveena
dc.creatorPillai, Kiran
dc.creatorIsmail, Zahra
dc.creatorHarky, Amer
dc.date.accessioned2020-08-05T15:54:20Z
dc.date.available2020-08-05T15:54:20Z
dc.date.created2020
dc.identifier.issn0024-3205spa
dc.identifier.otherhttps://doi.org/10.1016/j.lfs.2020.117788spa
dc.identifier.urihttp://hdl.handle.net/20.500.12010/11646
dc.description.abstractAims: As of the 28th April 2020, the COVID-19 pandemic has infiltrated over 200 countries and affected over three million confirmed people. We review different biomarkers to evaluate if they are able to predict clinical outcomes and correlate with the severity of COVID-19 disease. Methods: A systematic review of the literature was carried out to identify relevant articles using six different databases. Keywords to refine the search included ‘COVID-19’, ‘SARS-CoV2’, ‘Biomarkers’, among others. Only studies which reported data on pre-defined outcomes were included. Key findings: Thirty-four relevant articles were identified which reviewed the following biomarkers: C-reactive protein, serum amyloid A, interleukin-6, lactate dehydrogenase, neutrophil-to-lymphocyte ratio, D-dimer, cardiac troponin, renal biomarkers, lymphocytes and platelet count. Of these, all but two, showed significantly higher levels in patients with severe complications of COVID-19 infection compared to their non-severe counterparts. Lymphocytes and platelet count showed significantly lower levels in severe patients compared to nonsevere patients. Significance: Although research is still in its early stages, the discovery of how different biomarkers behave during the course of the disease could help clinicians in identifying severe disease earlier and subsequently improve prognosis. Nevertheless, we urge for more research across the globe to corroborate these findings.spa
dc.format.extent12 páginasspa
dc.format.mimetypeimage/jepgspa
dc.publisherScience Directeng
dc.publisherLife Sciences
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectSARS-CoV-2spa
dc.subjectCOVID-19spa
dc.subjectBiomarkersspa
dc.subjectBlood testsspa
dc.titleThe role of biomarkers in diagnosis of COVID-19 – A systematic reviewspa
dc.type.localArtículospa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.identifier.doihttps://doi.org/10.1016/j.lfs.2020.117788spa


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