Diabetes as a risk factor for greater COVID-19 severity and in- hospital death: A meta-analysis of observational studies
Byrne, Christopher D.
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Aims: To estimate the prevalence of established diabetes and its association with the clinical severity and in-hospital mortality associated with COVID-19. Data synthesis: We systematically searched PubMed, Scopus and Web of Science, from 1st January 2020 to 15th May 2020, for observational studies of patients admitted to hospital with COVID-19. Meta-analysis was performed using random-effects modeling. A total of 83 eligible studies with 78,874 hospitalized patients with laboratory-confirmed COVID-19 were included. The pooled prevalence of established diabetes was 14.34% (95% CI 12.62e16.06%). However, the prevalence of diabetes was higher in non-Asian vs. Asian countries (23.34% [95% CI 16.40 e30.28] vs. 11.06% [95% CI 9.73e12.39]), and in patients aged 60 years vs. those aged <60 years (23.30% [95% CI 19.65e26.94] vs. 8.79% [95% CI 7.56e10.02]). Pre-existing diabetes was associated with an approximate twofold higher risk of having severe/critical COVID-19 illness (n Z 22 studies; random-effects odds ratio 2.10, 95% CI 1.71e2.57; I 2 Z 41.5%) and ~threefold increased risk of in-hospital mortality (n Z 15 studies; random-effects odds ratio 2.68, 95% CI 2.09e3.44; I 2 Z 46.7%). Funnel plots and Egger’s tests did not reveal any significant publication bias.
Link to resourcehttps://doi.org/10.1016/j.numecd.2020.05.014
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