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Association of Blood Glucose Control and Outcomes in Patients with COVID-19 and Pre-existing Type 2 Diabetes
dc.creator | Zhu, Lihua | |
dc.creator | She, Zhi-Gang | |
dc.creator | Cheng, Xu | |
dc.creator | Guo, Jiao | |
dc.creator | Zhang, Bing-Hong | |
dc.creator | Li, Hongliang | |
dc.date.accessioned | 2020-07-31T18:57:08Z | |
dc.date.available | 2020-07-31T18:57:08Z | |
dc.date.created | 2020 | |
dc.identifier.issn | 1068–1077 | spa |
dc.identifier.other | https://doi.org/10.1016/j.cmet.2020.04.021 | spa |
dc.identifier.uri | http://hdl.handle.net/20.500.12010/11476 | |
dc.description.abstract | Type 2 diabetes (T2D) is a major comorbidity of COVID-19. However, the impact of blood glucose (BG) control on the degree of required medical interventions and on mortality in patients with COVID-19 and T2D remains uncertain. Thus, we performed a retrospective, multi-centered study of 7,337 cases of COVID-19 in Hubei Province, China, among which 952 had pre-existing T2D. We found that subjects with T2D required more medical interventions and had a significantly higher mortality (7.8% versus 2.7%; adjusted hazard ratio [HR], 1.49) and multiple organ injury than the non-diabetic individuals. Further, we found that well-controlled BG (glycemic variability within 3.9 to 10.0 mmol/L) was associated with markedly lower mortality compared to individuals with poorly controlled BG (upper limit of glycemic variability exceeding 10.0 mmol/L) (adjusted HR, 0.14) during hospitalization. These findings provide clinical evidence correlating improved glycemic control with better outcomes in patients with COVID-19 and pre-existing T2D. | spa |
dc.format.extent | 14 páginas | spa |
dc.format.mimetype | image/jepg | spa |
dc.publisher | Cell Metabolism | eng |
dc.source | reponame:Expeditio Repositorio Institucional UJTL | spa |
dc.source | instname:Universidad de Bogotá Jorge Tadeo Lozano | spa |
dc.subject | Blood glucose | spa |
dc.subject | COVID-19 | spa |
dc.subject | Patients | spa |
dc.title | Association of Blood Glucose Control and Outcomes in Patients with COVID-19 and Pre-existing Type 2 Diabetes | spa |
dc.type.local | Artículo | spa |
dc.subject.lemb | Síndrome respiratorio agudo grave | spa |
dc.subject.lemb | COVID-19 | spa |
dc.subject.lemb | SARS-CoV-2 | spa |
dc.subject.lemb | Coronavirus | spa |
dc.rights.accessrights | info:eu-repo/semantics/openAccess | spa |
dc.type.hasversion | info:eu-repo/semantics/acceptedVersion | spa |
dc.identifier.doi | https://doi.org/10.1016/j.cmet.2020.04.021 | spa |