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dc.creatorZhu, Lihua
dc.creatorShe, Zhi-Gang
dc.creatorCheng, Xu
dc.creatorGuo, Jiao
dc.creatorZhang, Bing-Hong
dc.creatorLi, Hongliang
dc.date.accessioned2020-07-31T18:57:08Z
dc.date.available2020-07-31T18:57:08Z
dc.date.created2020
dc.identifier.issn1068–1077spa
dc.identifier.otherhttps://doi.org/10.1016/j.cmet.2020.04.021spa
dc.identifier.urihttp://hdl.handle.net/20.500.12010/11476
dc.description.abstractType 2 diabetes (T2D) is a major comorbidity of COVID-19. However, the impact of blood glucose (BG) control on the degree of required medical interventions and on mortality in patients with COVID-19 and T2D remains uncertain. Thus, we performed a retrospective, multi-centered study of 7,337 cases of COVID-19 in Hubei Province, China, among which 952 had pre-existing T2D. We found that subjects with T2D required more medical interventions and had a significantly higher mortality (7.8% versus 2.7%; adjusted hazard ratio [HR], 1.49) and multiple organ injury than the non-diabetic individuals. Further, we found that well-controlled BG (glycemic variability within 3.9 to 10.0 mmol/L) was associated with markedly lower mortality compared to individuals with poorly controlled BG (upper limit of glycemic variability exceeding 10.0 mmol/L) (adjusted HR, 0.14) during hospitalization. These findings provide clinical evidence correlating improved glycemic control with better outcomes in patients with COVID-19 and pre-existing T2D.spa
dc.format.extent14 páginasspa
dc.format.mimetypeimage/jepgspa
dc.publisherCell Metabolismeng
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectBlood glucosespa
dc.subjectCOVID-19spa
dc.subjectPatientsspa
dc.titleAssociation of Blood Glucose Control and Outcomes in Patients with COVID-19 and Pre-existing Type 2 Diabetesspa
dc.type.localArtículospa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.identifier.doihttps://doi.org/10.1016/j.cmet.2020.04.021spa


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